Tbio SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein

Protein Summary

Description

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.

Uniprot Accession IDs

• Q8NC51
• Q5VU19
• Q5VU20
• Q5VU22
• Q8WUH0
• Q96SE2
• Q9BTY3
• Q9BUM4
• Q9Y367
• Q9Y4S3

Gene Name

• SERBP1

Ensembl ID

• ENST00000361219
• ENSP00000354591
• ENSG00000142864
• ENST00000370990
• ENSP00000360029
• ENST00000370994
• ENSP00000360033
• ENST00000370995
• ENSP00000360034

Symbol

• PAIRBP1
• CGI-55
• CHD3IP
• HABP4L
• PAIRBP1
• PAI-RBP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
disease perturbation	0.99
transcription factor perturbation	0.98
microRNA	0.96

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Plasminogen Activator Inhibitor 1 Rna-binding Protein

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Plasminogen Activator Inhibitor 1 Rna-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.9   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 309   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.9   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0