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Tbio
SERBP1
Plasminogen activator inhibitor 1 RNA-binding protein

Protein Summary
Description
May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361219
  • ENSP00000354591
  • ENSG00000142864
  • ENST00000370990
  • ENSP00000360029
  • ENST00000370994
  • ENSP00000360033
  • ENST00000370995
  • ENSP00000360034

Symbol
  • PAIRBP1
  • CGI-55
  • CHD3IP
  • HABP4L
  • PAIRBP1
  • PAI-RBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
disease perturbation
0.99
transcription factor perturbation
0.98
microRNA
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.59   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.59   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (197)
1 – 10 of 197
TBCE
Tbio
Novelty:  0.01058281
p_int:  0.998616923
p_ni:  0.001382919
p_wrong:  1.57e-7
Score:  0.636
Data Source:  BioPlex,STRINGDB
SNRPC
Tbio
Novelty:  0.02049921
p_int:  0.866374352
p_ni:  0.133625649
Score:  0.212
Data Source:  BioPlex,STRINGDB
SRSF2
Tbio
Novelty:  0.00207072
p_int:  0.863728871
p_ni:  0.136271129
Score:  0.311
Data Source:  BioPlex,STRINGDB
RPL21
Tbio
Novelty:  0.01023355
Score:  0.977
Data Source:  STRINGDB
RPS25
Tbio
Novelty:  0.02812798
Score:  0.974
Data Source:  STRINGDB
RPL8
Tbio
Novelty:  0.01064076
Score:  0.973
Data Source:  STRINGDB
RPL23
Tbio
Novelty:  0.02741113
Score:  0.972
Data Source:  STRINGDB
RPS18
Tbio
Novelty:  0.00688684
Score:  0.972
Data Source:  STRINGDB
RPL17
Tbio
Novelty:  0.02730924
Score:  0.972
Data Source:  STRINGDB
RPS19
Tbio
Novelty:  0.00380084
Score:  0.972
Data Source:  STRINGDB
Pathways (5)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Apoptosis-related network due to altered Notch3 in ovarian cancer
WikiPathways
Apoptosis-related network due to altered Notch3 in ovarian cancer
WikiPathways
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
WikiPathways
PI3K-Akt Signaling Pathway
WikiPathways
Regulatory circuits of the STAT3 signaling pathway
Name
Explore in Pharos
Explore in Source
Apoptosis-related network due to altered Notch3 in ovarian cancer
Apoptosis-related network due to altered Notch3 in ovarian cancer
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
PI3K-Akt Signaling Pathway
Regulatory circuits of the STAT3 signaling pathway
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
primary biliary cirrhosis
2
2
0
1.6
89.4
3
2
0
1.5
83.7
2
2
0
1.1
58.9
2
2
0
1.2
58.9
2
2
0
1.2
58.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
primary biliary cirrhosis
0
1.6
89.4
0
1.5
83.7
0
1.1
58.9
0
1.2
58.9
0
1.2
58.9
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SERPINE1 mRNA binding protein 1
VGNC:1539
456928
Macaque
SERPINE1 mRNA binding protein 1
700797
Mouse
MGI:1914120
66870
Rat
RGD:619907
246303
Dog
SERPINE1 mRNA binding protein 1
VGNC:46018
479535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SERPINE1 mRNA binding protein 1
Macaque
SERPINE1 mRNA binding protein 1
Mouse
Rat
Dog
SERPINE1 mRNA binding protein 1
Publication Statistics
PubMed Score 32.59
PubMed score by year
PubTator Score 18.45
PubTator score by year