Tdark RNF149 E3 ubiquitin-protein ligase RNF149

Protein Summary

Description

E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.

Uniprot Accession IDs

• Q8NC42
• Q53S14
• Q8N5I8
• Q8NBY5
• Q8WUU3

Gene Name

• RNF149

Ensembl ID

• ENST00000295317
• ENSP00000295317
• ENSG00000163162

Symbol

• DNAPTP2
• DNAPTP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
cell type or tissue	0.8
transcription factor binding site profile	0.74
tissue sample	0.7
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.51   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.51   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0