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Tdark
INO80E
INO80 complex subunit E

Protein Summary
Description
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000562441
  • ENSP00000456073
  • ENSG00000169592
  • ENST00000563197
  • ENSP00000457016
  • ENST00000567065
  • ENSP00000454665
  • ENST00000620599
  • ENSP00000484187

Symbol
  • CCDC95
  • CCDC95
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
histone modification site profile
0.83
cell type or tissue
0.7
cellular component
0.68
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.78   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.78   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
INO80
Tbio
Family:  Enzyme
Novelty:  0.09412936
p_int:  0.999999968
p_ni:  2.9e-8
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.999999743
p_ni:  2.56e-7
p_wrong:  1e-9
Score:  0.967
Data Source:  BioPlex,STRINGDB
INO80C
Tdark
Novelty:  0.04242834
p_int:  0.999999245
p_ni:  7.55e-7
Score:  0.951
Data Source:  BioPlex,STRINGDB
CCNDBP1
Tbio
Novelty:  0.01527762
p_int:  0.999985679
p_ni:  0.000013647
p_wrong:  6.73e-7
Score:  0.738
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.99997186
p_ni:  0.000002119
p_wrong:  0.000026021
Score:  0.968
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.999769743
p_ni:  9.48e-7
p_wrong:  0.000229309
Score:  0.972
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.997135862
p_ni:  0.000337103
p_wrong:  0.002527035
Score:  0.19
Data Source:  BioPlex,STRINGDB
ACTR5
Tbio
Novelty:  0.15502033
Score:  0.999
Data Source:  STRINGDB
NFRKB
Tbio
Novelty:  0.13445983
Score:  0.999
Data Source:  STRINGDB
MCRS1
Tbio
Novelty:  0.03404119
Score:  0.974
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
DNA Damage Recognition in GG-NER (R-HSA-5696394)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Global Genome Nucleotide Excision Repair (GG-NER)
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
5
6
96.4
appendicular lean mass
2
3
6
94.7
mean corpuscular volume
3
2
3
94
waist-hip ratio
3
3
3
89.1
red blood cell density measurement
2
1
2
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
96.4
appendicular lean mass
6
94.7
mean corpuscular volume
3
94
waist-hip ratio
3
89.1
red blood cell density measurement
2
87.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
INO80 complex subunit E
708115
Mouse
MGI:2141881
233875
Rat
RGD:1359572
293494
Dog
INO80 complex subunit E
VGNC:42026
489944
Horse
INO80 complex subunit E
VGNC:19068
100064084
Species
Name
OMA
EggNOG
Inparanoid
Macaque
INO80 complex subunit E
Mouse
Rat
Dog
INO80 complex subunit E
Horse
INO80 complex subunit E
Publication Statistics
PubMed Score 1.78
PubMed score by year
PubTator Score 1.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title