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Tbio
SLC38A9
Sodium-coupled neutral amino acid transporter 9

Protein Summary
Description
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead (PubMed:25561175, PubMed:25567906). The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor (PubMed:25567906).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318672
  • ENSP00000316596
  • ENSG00000177058
  • ENST00000396865
  • ENSP00000380074
  • ENST00000512595
  • ENSP00000427335
  • ENST00000515629
  • ENSP00000420934

Symbol
  • URLC11
  • URLC11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
virus perturbation
0.76
transcription factor perturbation
0.74
cell type or tissue
0.58
microRNA
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.56   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.56   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (98)
1 – 10 of 98
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.999996127
p_ni:  0.000002762
p_wrong:  0.000001111
Score:  0.999
Data Source:  BioPlex,STRINGDB
RRAGA
Tbio
Novelty:  0.02022668
p_int:  0.999994739
p_ni:  0.000005261
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LAMTOR1
Tbio
Novelty:  0.04952213
p_int:  0.999994177
p_ni:  0.000005823
Score:  0.999
Data Source:  BioPlex,STRINGDB
LAMTOR3
Tbio
Novelty:  0.050644
p_int:  0.999984374
p_ni:  0.000015618
p_wrong:  8e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999848067
p_ni:  0.000151933
Data Source:  BioPlex
LAMTOR4
Tdark
Novelty:  0.24218646
p_int:  0.999655856
p_ni:  0.000336731
p_wrong:  0.000007413
Score:  0.999
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999493887
p_ni:  0.000506112
Score:  0.217
Data Source:  BioPlex,STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.999464393
p_ni:  0.000514957
p_wrong:  0.000020651
Data Source:  BioPlex
LGALS9C
Tdark
Novelty:  0.29969898
p_int:  0.999046043
p_ni:  0.000953957
Score:  0.568
Data Source:  BioPlex,STRINGDB
ASGR2
Tbio
Novelty:  0.14671716
p_int:  0.99840503
p_ni:  0.00159497
Score:  0.185
Data Source:  BioPlex,STRINGDB
Pathways (17)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Energy dependent regulation of mTOR by LKB1-AMPK
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
5
5
90.8
BMI-adjusted waist-hip ratio
2
5
5
88
waist-hip ratio
2
6
6
87
BMI-adjusted waist circumference
1
4
4
81.5
heel bone mineral density
3
2
5
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
90.8
BMI-adjusted waist-hip ratio
5
88
waist-hip ratio
6
87
BMI-adjusted waist circumference
4
81.5
heel bone mineral density
5
80.3
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 38 member 9
VGNC:8645
461868
Macaque
solute carrier family 38 member 9
706752
Mouse
MGI:1918839
268706
Rat
RGD:1311881
310091
Dog
solute carrier family 38 member 9
VGNC:46399
487210
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 38 member 9
Macaque
solute carrier family 38 member 9
Mouse
Rat
Dog
solute carrier family 38 member 9
Publication Statistics
PubMed Score 16.56
PubMed score by year
PubTator Score 9.70
PubTator score by year