Protein Summary
Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity). This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
- ENST00000381968
- ENSP00000371394
- ENSG00000149043
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.79 | ||
gene perturbation | 0.65 | ||
molecular function | 0.56 | ||
transcription factor | 0.56 | ||
cellular component | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.41 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 83 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.41 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 83 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (165)
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (7)
Components (7)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cathepsin D measurement | 1 | 2 | 2 | 95.9 | |||||
monocyte count | 2 | 1 | 2 | 85.4 | |||||
blood protein measurement | 1 | 1 | 1 | 82.8 | |||||
monocyte percentage of leukocytes | 2 | 1 | 2 | 82.6 | |||||
1 | 3 | 3 | 82 | ||||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cathepsin D measurement | 2 | 95.9 | |||||
monocyte count | 2 | 85.4 | |||||
blood protein measurement | 1 | 82.8 | |||||
monocyte percentage of leukocytes | 2 | 82.6 | |||||
3 | 82 | ||||||
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IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | synaptotagmin 8 | VGNC:3046 | 466316 | |||||
Mouse | MGI:1859867 | 55925 | ||||||
Rat | RGD:68399 | 60566 | ||||||
Dog | synaptotagmin 8 | VGNC:47051 | 611547 | |||||
Cow | synaptotagmin 8 [Source:HGNC Symbol;Acc:HGNC:19264] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | synaptotagmin 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | synaptotagmin 8 | |||||
Cow | synaptotagmin 8 [Source:HGNC Symbol;Acc:HGNC:19264] | |||||
Publication Statistics
PubMed Score 18.41
PubMed score by year
PubTator Score 4.48
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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