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Tbio
ATAD1
ATPase family AAA domain-containing protein 1

Protein Summary
Description
ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308448
  • ENSP00000339017
  • ENSG00000138138
  • ENST00000328142
  • ENSP00000339016
  • ENST00000634773
  • ENSP00000489353
  • ENSG00000283024
  • ENST00000634970
  • ENSP00000489455

Symbol
  • AFDC1
  • HKPX4
  • FNP001
  • THORASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
histone modification site profile
0.88
virus perturbation
0.79
transcription factor binding site profile
0.75
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.26   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.26   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0