You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPC24
Kinetochore protein Spc24

Protein Summary
Description
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000592540
  • ENSP00000465075
  • ENSG00000161888

Symbol
  • SPBC24
  • SPBC24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.72
cellular component
0.69
tissue sample
0.62
transcription factor
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.56   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.56   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
3
5
3.4
96.1
total cholesterol measurement
3
2
2
3.2
94.9
1
1
0
1.1
40
apolipoprotein A 1 measurement
1
1
1
10.6
reticulocyte count
2
1
2
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
3.4
96.1
total cholesterol measurement
2
3.2
94.9
0
1.1
40
apolipoprotein A 1 measurement
1
10.6
reticulocyte count
2
4.8
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (7)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (188)
1 – 10 of 188
SPC25
Tbio
Novelty: 0.26354244
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NSL1
Tbio
Novelty: 0.01396984
p_int: 1
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
DSN1
Tbio
Novelty: 0.05336903
p_int: 0.999999999
p_ni: 1e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
PMF1
Tbio
Novelty: 0.05319446
p_int: 0.999999927
p_ni: 7.3e-8
Score: 0.458
Data Source: BioPlex,Reactome,STRINGDB
NDC80
Tbio
Novelty: 0.00331814
p_int: 0.999999816
p_ni: 1.84e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NUF2
Tbio
Novelty: 0.01069726
p_int: 0.999999767
p_ni: 2.33e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MIS12
Tbio
Novelty: 0.05345698
p_int: 0.999998465
p_ni: 0.000001535
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
KNL1
Tbio
Novelty: 0.01084826
p_int: 0.999993154
p_ni: 0.000006846
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
ZWINT
Tbio
Novelty: 0.02153276
p_int: 0.999918493
p_ni: 0.000081507
Score: 0.997
Data Source: BioPlex,STRINGDB
EMILIN1
Tbio
Novelty: 0.02550566
p_int: 0.998393086
p_ni: 0.001606914
Data Source: BioPlex
Publication Statistics
PubMed Score  28.56

PubMed score by year
PubTator Score  7.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: