Tbio TXNDC5 Thioredoxin domain-containing protein 5

Protein Summary

Description

Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q8NBS9
• B2RDM2
• Q5TCQ0
• Q8ND33
• Q8TCT2
• Q9BVH9

Gene Name

• TXNDC5

Ensembl ID

• ENST00000379757
• ENSP00000369081
• ENSG00000239264
• ENST00000473453
• ENSP00000420784

Symbol

• TLP46
• HCC2
• ERP46
• HCC-2
• STRF8
• PDIA15
• UNQ364
• ENDOPDI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
small molecule perturbation	0.93
kinase perturbation	0.76
cellular component	0.73
transcription factor binding site profile	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.96   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 462   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.96   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 462   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0