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Tbio
TXNDC5
Thioredoxin domain-containing protein 5

Protein Summary
Description
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379757
  • ENSP00000369081
  • ENSG00000239264
  • ENST00000473453
  • ENSP00000420784

Symbol
  • TLP46
  • HCC2
  • ERP46
  • HCC-2
  • STRF8
  • PDIA15
  • UNQ364
  • ENDOPDI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
small molecule perturbation
0.93
kinase perturbation
0.76
cellular component
0.73
transcription factor binding site profile
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.29   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 462   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.29   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 462   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
2
2
1
30.9
90.3
BMI-adjusted hip circumference
3
3
3
76.5
forced expiratory volume
1
1
1
76.4
mean corpuscular hemoglobin concentration
1
1
1
63.1
brain stem volume measurement
1
1
0
6.3
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
30.9
90.3
BMI-adjusted hip circumference
3
76.5
forced expiratory volume
1
76.4
mean corpuscular hemoglobin concentration
1
63.1
brain stem volume measurement
0
6.3
39.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin domain containing 5
VGNC:13043
100615889
Macaque
thioredoxin domain containing 5
695213
Mouse
MGI:2145316
105245
Rat
RGD:2323973
100362805
Dog
thioredoxin domain containing 5
VGNC:48015
100683583
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin domain containing 5
Macaque
thioredoxin domain containing 5
Mouse
Rat
Dog
thioredoxin domain containing 5
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NBS9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Lysosome Vesicle Biogenesis
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Immune System
Innate Immune System
Lysosome Vesicle Biogenesis
Membrane Trafficking
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (190)
1 – 10 of 190
SPTB
Tbio
Novelty:  0.00467504
p_int:  0.999991307
p_ni:  0.000008676
p_wrong:  1.7e-8
Score:  0.296
Data Source:  BioPlex,STRINGDB
VRK3
Tbio
Family:  Kinase
Novelty:  0.15665279
p_int:  0.999960283
p_ni:  0.000001746
p_wrong:  0.000037971
Score:  0.284
Data Source:  BioPlex,STRINGDB
JMJD8
Tbio
Novelty:  0.31175159
p_int:  0.997458653
p_ni:  0.001344519
p_wrong:  0.001196828
Score:  0.274
Data Source:  BioPlex,STRINGDB
WDR59
Tdark
Novelty:  0.22243351
p_int:  0.943032915
p_ni:  0.056967085
Score:  0.25
Data Source:  BioPlex,STRINGDB
KLHL26
Tdark
Novelty:  1.53240393
p_int:  0.865300749
p_ni:  0.13469923
p_wrong:  2e-8
Score:  0.204
Data Source:  BioPlex,STRINGDB
PRDX4
Tbio
Novelty:  0.00692103
Score:  0.97
Data Source:  STRINGDB
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
Score:  0.953
Data Source:  STRINGDB
PRDX6
Tbio
Novelty:  0.00180564
Score:  0.949
Data Source:  STRINGDB
GDI2
Tbio
Novelty:  0.02861013
Score:  0.941
Data Source:  STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.937
Data Source:  STRINGDB
Publication Statistics
PubMed Score  56.29

PubMed score by year
PubTator Score  31.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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