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Tbio
SLC4A11
Sodium bicarbonate transporter-like protein 11

Protein Summary
Description
Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380056
  • ENSP00000369396
  • ENSG00000088836
  • ENST00000380059
  • ENSP00000369399
  • ENST00000539553
  • ENSP00000441370
  • ENST00000642402
  • ENSP00000493503

Symbol
  • BTR1
  • BTR1
  • CHED
  • CDPD1
  • CHED2
  • NABC1
  • dJ794I6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
histone modification site profile
0.83
gene perturbation
0.71
protein domain
0.58
transcription factor
0.58


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.09   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.09   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
13.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
13.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 11
VGNC:9986
458058
Macaque
solute carrier family 4 member 11
718393
Mouse
MGI:2138987
269356
Rat
RGD:1310188
311423
Dog
solute carrier family 4 member 11
VGNC:46431
485796
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 11
Macaque
solute carrier family 4 member 11
Mouse
Rat
Dog
solute carrier family 4 member 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NBS3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (17)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (51)
1 – 10 of 51
COL8A2
Tbio
Novelty: 0.01672103
Score: 0.908
Data Source: STRINGDB
LOXHD1
Tbio
Family: Enzyme
Novelty: 0.06557997
Score: 0.786
Data Source: STRINGDB
CHST6
Tbio
Family: Enzyme
Novelty: 0.01917947
Score: 0.679
Data Source: STRINGDB
AGBL1
Tdark
Family: Enzyme
Novelty: 0.01351077
Score: 0.659
Data Source: STRINGDB
CYYR1
Tbio
Novelty: 0.19732526
Score: 0.607
Data Source: STRINGDB
UBIAD1
Tbio
Family: Enzyme
Novelty: 0.02238863
Score: 0.606
Data Source: STRINGDB
RPL31
Tbio
Novelty: 0.03427872
Score: 0.577
Data Source: STRINGDB
SLC5A1
Tclin
Family: Transporter
Novelty: 0.00113611
Score: 0.576
Data Source: STRINGDB
SUCLG1
Tbio
Family: Enzyme
Novelty: 0.01113643
Score: 0.571
Data Source: STRINGDB
VSX1
Tbio
Family: TF
Novelty: 0.01213324
Score: 0.567
Data Source: STRINGDB
Publication Statistics
PubMed Score  122.09

PubMed score by year
PubTator Score  60.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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