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Tbio
SLC4A11
Sodium bicarbonate transporter-like protein 11

Protein Summary
Description
Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380056
  • ENSP00000369396
  • ENSG00000088836
  • ENST00000380059
  • ENSP00000369399
  • ENST00000539553
  • ENSP00000441370
  • ENST00000642402
  • ENSP00000493503

Symbol
  • BTR1
  • BTR1
  • CHED
  • CDPD1
  • CHED2
  • NABC1
  • dJ794I6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
histone modification site profile
0.83
gene perturbation
0.71
protein domain
0.58
transcription factor
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.99   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.99   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0