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Tbio
UBAC2
Ubiquitin-associated domain-containing protein 2

Protein Summary
Description
Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376440
  • ENSP00000365623
  • ENSG00000134882
  • ENST00000403766
  • ENSP00000383911

Symbol
  • PHGDHL1
  • PHGDHL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
transcription factor perturbation
0.61
histone modification site profile
0.59
cell line
0.57
tissue sample
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.91   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.91   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
90.1
4
4
0
1.1
77.7
2
2
0
1.1
77.1
eosinophil percentage of leukocytes
2
2
2
66.8
childhood onset asthma
2
1
0
1.1
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
90.1
0
1.1
77.7
0
1.1
77.1
eosinophil percentage of leukocytes
2
66.8
childhood onset asthma
0
1.1
65.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UBA domain containing 2
VGNC:5129
740191
Macaque
UBA domain containing 2
703484
Mouse
MGI:1916139
68889
Rat
RGD:1311689
361094
Dog
UBA domain containing 2
VGNC:48043
608309
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UBA domain containing 2
Macaque
UBA domain containing 2
Mouse
Rat
Dog
UBA domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NBM4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (98)
1 – 10 of 98
HAL
Tbio
Family: Enzyme
Novelty: 0.01504631
p_int: 0.996894898
p_ni: 0.003105102
Data Source: BioPlex
KLK7
Tchem
Family: Enzyme
Novelty: 0.00757766
p_int: 0.97651753
p_ni: 0.023480981
p_wrong: 0.000001489
Score: 0.211
Data Source: BioPlex,STRINGDB
CPA4
Tbio
Family: Enzyme
Novelty: 0.01439845
p_int: 0.960323525
p_ni: 0.039676406
p_wrong: 6.9e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
TBC1D15
Tbio
Novelty: 0.11296513
p_int: 0.950919958
p_ni: 0.049080042
Score: 0.698
Data Source: BioPlex,STRINGDB
KPRP
Tdark
Novelty: 0.11744927
p_int: 0.93942754
p_ni: 0.060562253
p_wrong: 0.000010207
Score: 0.198
Data Source: BioPlex,STRINGDB
SLC17A2
Tdark
Family: Transporter
Novelty: 0.23941275
p_int: 0.858171463
p_ni: 0.141828537
Data Source: BioPlex
PCYOX1
Tbio
Family: Enzyme
Novelty: 0.18505748
p_int: 0.830437973
p_ni: 0.169562027
Score: 0.204
Data Source: BioPlex,STRINGDB
FAF2
Tbio
Novelty: 0.03048598
p_int: 0.821589141
p_ni: 0.178410859
Score: 0.992
Data Source: BioPlex,STRINGDB
S100A16
Tbio
Novelty: 0.2386365
p_int: 0.811156454
p_ni: 0.188843545
p_wrong: 1e-9
Score: 0.455
Data Source: BioPlex,STRINGDB
AMFR
Tbio
Family: Enzyme
Novelty: 0.00533547
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.91

PubMed score by year
PubTator Score  4.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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