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Tbio
SUMF1
Formylglycine-generating enzyme

Protein Summary
Description
Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:25931126, PubMed:16368756, PubMed:21224894). 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:25931126, PubMed:16368756). Known substrates include GALNS, ARSA, STS and ARSE (PubMed:12757706, PubMed:15907468, PubMed:15657036). This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272902
  • ENSP00000272902
  • ENSG00000144455
  • ENST00000383843
  • ENSP00000373355
  • ENST00000405420
  • ENSP00000384977

Symbol
  • FGE
  • UNQ3037
  • AAPA3037
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
histone modification site profile
0.9
transcription factor binding site profile
0.74
disease
0.65
tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.79   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.79   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (60)
1 – 10 of 60
ARSA
Tbio
Family:  Enzyme
Novelty:  0.00469851
p_int:  0.999988965
p_ni:  0.000011011
p_wrong:  2.3e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
p_int:  0.999980951
p_ni:  0.000019049
Score:  0.846
Data Source:  BioPlex,STRINGDB
ARSE
Tbio
Family:  Enzyme
Novelty:  0.00151862
p_int:  0.999950965
p_ni:  0.000049035
Score:  0.968
Data Source:  BioPlex,STRINGDB
IDS
Tbio
Family:  Enzyme
Novelty:  0.00733996
p_int:  0.999931869
p_ni:  0.00006813
Score:  0.872
Data Source:  BioPlex,STRINGDB
ARSG
Tbio
Family:  Enzyme
Novelty:  0.04412917
p_int:  0.999694438
p_ni:  0.000305561
p_wrong:  1e-9
Score:  0.976
Data Source:  BioPlex,STRINGDB
SGSH
Tbio
Family:  Enzyme
Novelty:  0.00670111
p_int:  0.999261981
p_ni:  0.000738018
p_wrong:  1e-9
Score:  0.869
Data Source:  BioPlex,STRINGDB
GNS
Tbio
Family:  Enzyme
Novelty:  0.01528509
p_int:  0.998899008
p_ni:  0.001094779
p_wrong:  0.000006213
Score:  0.759
Data Source:  BioPlex,STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
p_int:  0.99881003
p_ni:  0.001021465
p_wrong:  0.000168505
Score:  0.973
Data Source:  BioPlex,STRINGDB
PNLIP
Tclin
Family:  Enzyme
Novelty:  0.00043254
p_int:  0.994232692
p_ni:  0.005765347
p_wrong:  0.00000196
Score:  0.189
Data Source:  BioPlex,STRINGDB
LY86
Tbio
Novelty:  0.00314575
p_int:  0.98265484
p_ni:  0.009212407
p_wrong:  0.008132753
Data Source:  BioPlex
Pathways (10)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
5
60.1
self reported educational attainment
1
1
1
28.1
Myopia
1
1
0
5.7
26.1
refractive error measurement
1
1
0
5.7
26.1
age at onset
1
1
0
5.7
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
5
60.1
self reported educational attainment
1
28.1
Myopia
0
5.7
26.1
refractive error measurement
0
5.7
26.1
age at onset
0
5.7
26.1
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sulfatase modifying factor 1
VGNC:12201
470739
Macaque
sulfatase modifying factor 1
704112
Mouse
MGI:1889844
58911
Rat
RGD:1309939
362409
Dog
sulfatase modifying factor 1
VGNC:46982
484681
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sulfatase modifying factor 1
Macaque
sulfatase modifying factor 1
Mouse
Rat
Dog
sulfatase modifying factor 1
Publication Statistics
PubMed Score 97.79
PubMed score by year
PubTator Score 67.55
PubTator score by year