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Tbio
COLGALT1
Procollagen galactosyltransferase 1

Protein Summary
Description
Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836). By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836). The protein encoded by this gene is one of two enzymes that transfers galactose moieties to hydroxylysine residues of collagen and mannose binding lectin. This gene is constitutively expressed and encodes a soluble protein that localizes to the endoplasmic reticulum. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252599
  • ENSP00000252599
  • ENSG00000130309

Symbol
  • GLT25D1
  • BSVD3
  • GLT25D1
  • ColGalT 1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
interacting protein
0.9
histone modification site profile
0.76
tissue sample
0.66
transcription factor binding site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.95   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.95   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
18.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen beta(1-O)galactosyltransferase 1
VGNC:14840
455843
Macaque
procollagen galactosyltransferase 1
719980
Mouse
MGI:1924348
234407
Rat
RGD:1309002
290637
Dog
collagen beta(1-O)galactosyltransferase 1
VGNC:54592
484834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen beta(1-O)galactosyltransferase 1
Macaque
procollagen galactosyltransferase 1
Mouse
Rat
Dog
collagen beta(1-O)galactosyltransferase 1
Pathways (5)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (84)
1 – 10 of 84
COLGALT2
Tbio
Family: Enzyme
Novelty: 0.15981994
p_int: 0.950044201
p_ni: 0.049955799
Score: 0.934
Data Source: BioPlex,STRINGDB
PLOD3
Tbio
Family: Enzyme
Novelty: 0.02211629
Score: 0.958
Data Source: STRINGDB
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
Score: 0.956
Data Source: STRINGDB
PLOD2
Tbio
Family: Enzyme
Novelty: 0.00403916
Score: 0.947
Data Source: STRINGDB
COL11A2
Tbio
Novelty: 0.00923441
Score: 0.913
Data Source: STRINGDB
COL19A1
Tbio
Novelty: 0.15030115
Score: 0.911
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.91
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.907
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.906
Data Source: STRINGDB
COL4A6
Tbio
Novelty: 0.02524039
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.95

PubMed score by year
PubTator Score  3.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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