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Tbio
XXYLT1
Xyloside xylosyltransferase 1

Protein Summary
Description
Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310380
  • ENSP00000309640
  • ENSG00000173950
  • ENST00000356740
  • ENSP00000349179
  • ENST00000437101
  • ENSP00000409865

Symbol
  • C3orf21
  • C3orf21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
histone modification site profile
0.79
transcription factor
0.62
cell line
0.6
cellular component
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
69.6
1
1
0
1.3
49.9
1
1
0
1.1
27.6
body height
1
1
1
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
69.6
0
1.3
49.9
0
1.1
27.6
body height
1
10
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
xyloside xylosyltransferase 1
VGNC:2631
460947
Macaque
xyloside xylosyltransferase 1
708627
Mouse
MGI:2146443
268880
Rat
RGD:1308154
363799
Cow
xyloside xylosyltransferase 1
VGNC:53613
533703
Species
Name
OMA
EggNOG
Inparanoid
Chimp
xyloside xylosyltransferase 1
Macaque
xyloside xylosyltransferase 1
Mouse
Rat
Cow
xyloside xylosyltransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NBI6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (42)
1 – 10 of 42
MPP1
Tbio
Novelty: 0.08674817
p_int: 0.999999176
p_ni: 8.25e-7
Data Source: BioPlex
SLC30A1
Tbio
Family: Transporter
Novelty: 0.00528427
p_int: 0.999990332
p_ni: 0.000009668
Data Source: BioPlex
CLYBL
Tbio
Family: Enzyme
Novelty: 0.02183572
p_int: 0.999956257
p_ni: 1.5e-8
p_wrong: 0.000043728
Data Source: BioPlex
SPG21
Tbio
Family: Enzyme
Novelty: 0.07929043
p_int: 0.999889559
p_ni: 0.000008671
p_wrong: 0.00010177
Data Source: BioPlex
PRMT3
Tchem
Family: Epigenetic
Novelty: 0.03433797
p_int: 0.999368112
p_ni: 0.000631875
p_wrong: 1.3e-8
Data Source: BioPlex
PLAA
Tchem
Family: Enzyme
Novelty: 0.01164687
p_int: 0.997790087
p_ni: 0.002209913
Data Source: BioPlex
TYSND1
Tbio
Family: Enzyme
Novelty: 0.16036122
p_int: 0.994311485
p_ni: 0.005688515
Data Source: BioPlex
DCP2
Tbio
Family: Enzyme
Novelty: 0.00661786
p_int: 0.991784884
p_ni: 0.00821412
p_wrong: 9.96e-7
Data Source: BioPlex
SCN3B
Tbio
Family: IC
Novelty: 0.0438123
p_int: 0.986014598
p_ni: 0.013985402
Data Source: BioPlex
NOTCH2
Tchem
Novelty: 0.00195617
p_int: 0.979286285
p_ni: 0.020713715
Score: 0.292
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.27

PubMed score by year
PubTator Score  3.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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