Tbio XXYLT1 Xyloside xylosyltransferase 1

Protein Summary

Description

Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869).

Uniprot Accession IDs

• Q8NBI6
• D3DNW5
• Q8NAL3
• Q8WV03
• Q96ME0

Gene Name

• XXYLT1

Ensembl ID

• ENST00000310380
• ENSP00000309640
• ENSG00000173950
• ENST00000356740
• ENSP00000349179
• ENST00000437101
• ENSP00000409865

Symbol

• C3orf21
• C3orf21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.95
histone modification site profile	0.79
transcription factor	0.62
cell line	0.6
cellular component	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.51   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.51   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0