Tbio DRAXIN Draxin

Protein Summary

Description

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.

Uniprot Accession IDs

• Q8NBI3
• B6EV15
• Q5SNX0
• Q6UWK8

Gene Name

• DRAXIN

Ensembl ID

• ENST00000294485
• ENSP00000294485
• ENSG00000162490

Symbol

• C1orf187
• UNQ3119
• neucrin
• AGPA3119
• C1orf187

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.63
tissue	0.45
cell line	0.44
tissue sample	0.41
transcription factor	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.2   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.2   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0