You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NHLRC2
NHL repeat-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369301
  • ENSP00000358307
  • ENSG00000196865

Symbol
  • FINCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.94
histone modification site profile
0.88
transcription factor binding site profile
0.75
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.2   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.2   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.998520005
p_ni:  0.001479995
Score:  0.188
Data Source:  BioPlex,STRINGDB
SRSF2
Tbio
Novelty:  0.00207072
p_int:  0.93861613
p_ni:  0.061383835
p_wrong:  3.4e-8
Data Source:  BioPlex
ALDOA
Tbio
Family:  Enzyme
Novelty:  0.00517474
Score:  0.904
Data Source:  STRINGDB
FAM49B
Tbio
Novelty:  0.02928708
Score:  0.903
Data Source:  STRINGDB
ACTN1
Tbio
Novelty:  0.00654004
Score:  0.902
Data Source:  STRINGDB
VWF
Tclin
Novelty:  0.00009007
Score:  0.902
Data Source:  STRINGDB
SPARC
Tbio
Novelty:  0.00063267
Score:  0.902
Data Source:  STRINGDB
ACTN4
Tbio
Novelty:  0.0040236
Score:  0.902
Data Source:  STRINGDB
PROS1
Tbio
Novelty:  0.00275184
Score:  0.902
Data Source:  STRINGDB
ACTN2
Tbio
Novelty:  0.00615882
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
46
factor VII activating protease measurement
1
1
0
281.9
33
myeloid white cell count
1
1
1
17.3
leukocyte count
1
1
1
13.7
diastolic blood pressure
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
46
factor VII activating protease measurement
0
281.9
33
myeloid white cell count
1
17.3
leukocyte count
1
13.7
diastolic blood pressure
1
7.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NHL repeat containing 2
VGNC:4962
450748
Macaque
NHL repeat containing 2
698009
Mouse
MGI:1914116
66866
Rat
RGD:1307348
307986
Dog
NHL repeat containing 2
VGNC:43801
486897
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NHL repeat containing 2
Macaque
NHL repeat containing 2
Mouse
Rat
Dog
NHL repeat containing 2
Publication Statistics
PubMed Score 10.20
PubMed score by year
PubTator Score 2.75
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title