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Tbio
GLIS1
Zinc finger protein GLIS1

Protein Summary
Description
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312233
  • ENSP00000309653
  • ENSG00000174332
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
molecular function
0.73
biological process
0.62
protein domain
0.58
tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.5   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.5   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
3
3
92.8
synophrys measurement
1
1
1
70.1
grip strength measurement
2
2
2
70
digit length ratio
3
1
4
63.6
nose morphology measurement
1
1
1
23.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
3
92.8
synophrys measurement
1
70.1
grip strength measurement
2
70
digit length ratio
4
63.6
nose morphology measurement
1
23.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GLIS family zinc finger 1
VGNC:11440
738808
Macaque
GLIS family zinc finger 1
716224
Mouse
MGI:2386723
230587
Rat
RGD:1308030
298732
Dog
GLIS family zinc finger 1
VGNC:49872
489582
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GLIS family zinc finger 1
Macaque
GLIS family zinc finger 1
Mouse
Rat
Dog
GLIS family zinc finger 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NBF1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (29)
1 – 10 of 29
SPRR1B
Tbio
Novelty: 0.0320028
Score: 0.711
Data Source: STRINGDB
TSC1
Tbio
Novelty: 0.00406614
Score: 0.691
Data Source: STRINGDB
CAMK4
Tbio
Family: Kinase
Novelty: 0.00412444
Score: 0.647
Data Source: STRINGDB
KLK7
Tchem
Family: Enzyme
Novelty: 0.00757766
Score: 0.641
Data Source: STRINGDB
KLK6
Tchem
Family: Enzyme
Novelty: 0.00488956
Score: 0.609
Data Source: STRINGDB
FGF18
Tbio
Novelty: 0.00802997
Score: 0.593
Data Source: STRINGDB
MYCL
Tbio
Family: TF
Novelty: 0.0034508
Score: 0.578
Data Source: STRINGDB
LIN28A
Tbio
Family: TF
Novelty: 0.00199524
Score: 0.549
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.542
Data Source: STRINGDB
NR2C1
Tbio
Family: NR
Novelty: 0.03923956
Score: 0.541
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.50

PubMed score by year
PubTator Score  7.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer