Tbio KDM1B Lysine-specific histone demethylase 1B

Protein Summary

Description

Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]

Uniprot Accession IDs

• Q8NB78
• A2A2C5
• A2A2C6
• Q5TGV3
• Q6AI15
• Q6ZUU4
• Q8N258
• Q96EL7

Gene Name

• KDM1B

Ensembl ID

• ENST00000297792
• ENSP00000297792
• ENSG00000165097

Symbol

• AOF1
• C6orf193
• LSD2
• AOF1
• LSD2
• C6orf193

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.84
histone modification site profile	0.75
protein domain	0.73
transcription factor	0.7
biological process	0.66

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Dna Methyltransferase / Lysine-specific Histone Demethylase 1b

Protein / Oxidoreductase / Oxidase / Lysine-specific Histone Demethylase 1b

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Methyltransferase / Lysine-specific Histone Demethylase 1b

DTO Classes

Protein / Epigenetic Regulator / Eraser / Lysine Demethylase / Lysine-specific Demethylase / Lysine-specific Histone Demethylase 1b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.7   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.7   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0