ATP11C
Phospholipid-transporting ATPase IG
Protein Summary
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages (PubMed:26944472). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity).
- ENST00000327569
- ENSP00000332756
- ENSG00000101974
- ENST00000361648
- ENSP00000355165
- ATPIG
- ATPIQ
- ATPIG
- ATPIQ
- HACXL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
metabolite | 0.98 | ||
protein domain | 0.92 | ||
phenotype | 0.76 | ||
microRNA | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.73 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 95 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.73 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 95 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (74)
MBLAC2
Family: Enzyme
Novelty: 0.47407992
p_int: 0.999938015
p_ni: 0.000061985
Score: 0.15
Data Source: BioPlex,STRINGDB
NKAIN1
Family: Enzyme
Novelty: 0.52190272
p_int: 0.998754544
p_ni: 0.001245456
Data Source: BioPlex
SLC22A2
Family: Transporter
Novelty: 0.00439263
p_int: 0.996907112
p_ni: 0.003092883
p_wrong: 5e-9
Data Source: BioPlex
GPR21
Family: GPCR
Novelty: 0.90865557
p_int: 0.989267009
p_ni: 0.010732991
Data Source: BioPlex
P2RY1
Family: GPCR
Novelty: 0.00203299
p_int: 0.988197241
p_ni: 0.011802759
Score: 0.179
Data Source: BioPlex,STRINGDB
MUC1
Novelty: 0.00024203
p_int: 0.986544526
p_ni: 0.013455474
Score: 0.18
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Ion transport by P-type ATPases | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Ion transport by P-type ATPases | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (7)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 1 | 1 | 1 | 47.7 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 1 | 47.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ATPase phospholipid transporting 11C | VGNC:7635 | 465889 | |||||
Macaque | ATPase phospholipid transporting 11C | 695802 | ||||||
Mouse | MGI:1859661 | 320940 | ||||||
Rat | RGD:1564481 | 317599 | ||||||
Dog | ATPase phospholipid transporting 11C | VGNC:38239 | 481066 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ATPase phospholipid transporting 11C | |||||
Macaque | ATPase phospholipid transporting 11C | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATPase phospholipid transporting 11C | |||||
Publication Statistics
PubMed Score 20.73
PubMed score by year
PubTator Score 6.66
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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