Tdark FAM184A Protein FAM184A

Protein Summary

Uniprot Accession IDs

• Q8NB25
• B9DI75
• F8W8D6
• Q5TBS9
• Q7Z323
• Q96GY8
• Q9H0J8
• Q9H851

Gene Name

• FAM184A

Ensembl ID

• ENST00000338891
• ENSP00000342604
• ENSG00000111879
• ENST00000352896
• ENSP00000326608
• ENST00000521531
• ENSP00000430442

Symbol

• C6orf60
• C6orf60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
tissue sample	0.64
small molecule perturbation	0.6
tissue	0.55
transcription factor binding site profile	0.54

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.33   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.33   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	1	1	1		87.5
schizophrenia	EFO_0000692	1	1	1		33.4
self reported educational attainment	EFO_0004784	1	1	1		33.4
intelligence	EFO_0004337	1	1	1		33.4
electrocardiography	EFO_0004327	1	1	3		15.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	1		87.5
schizophrenia	EFO_0000692	1		33.4
self reported educational attainment	EFO_0004784	1		33.4
intelligence	EFO_0004337	1		33.4
electrocardiography	EFO_0004327	3		15.1

Reset Zoom  Beta Count   Odds Ratio

Gene Ontology Terms (1)

Components (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
extracellular space	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (14)

Explore Interacting Targets

1 – 10 of 14

• See Interactions on String-DB

CDR2

Tbio

Novelty: 0.00141419

p_int: 0.999999988

p_ni: 3e-9

p_wrong: 9e-9

Score: 0.224

Data Source: BioPlex,STRINGDB

LRRC61

Tdark

Novelty: 1.45343096

p_int: 0.99999982

p_ni: 1.8e-7

Data Source: BioPlex

PLEKHO2

Tdark

Novelty: 0.48296621

p_int: 0.999996073

p_ni: 0.000003911

p_wrong: 1.6e-8

Score: 0.332

Data Source: BioPlex,STRINGDB

PROM2

Tbio

Novelty: 0.0446718

Score: 0.62

Data Source: STRINGDB

CEP95

Tdark

Novelty: 1.18897795

Score: 0.566

Data Source: STRINGDB

CAMTA2

Tbio

Family: TF

Novelty: 0.06741618

Score: 0.557

Data Source: STRINGDB

ANAPC7

Tbio

Family: Enzyme

Novelty: 0.17956785

Score: 0.526

Data Source: STRINGDB

CEP250

Tbio

Novelty: 0.08014712

Score: 0.512

Data Source: STRINGDB

LRRC8D

Tbio

Novelty: 0.10536285

Score: 0.497

Data Source: STRINGDB

C9orf131

Tdark

Novelty: 17.32394366

Score: 0.494

Data Source: STRINGDB

Publication Statistics

PubMed Score  0.33

PubMed score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

Alternative splicing
Coiled coil
Complete proteome
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

electrocardiography
intelligence
schizophrenia
self reported educational attainment
testosterone measurement