Tbio SMYD1 Histone-lysine N-methyltransferase SMYD1

Protein Summary

Description

Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.

Uniprot Accession IDs

• Q8NB12
• A0AV30
• A6NE13

Gene Name

• SMYD1

Ensembl ID

• ENST00000419482
• ENSP00000393453
• ENSG00000115593

Symbol

• BOP
• KMT3D
• ZMYND18
• ZMYND22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.84
biological process	0.78
microRNA	0.6
PubMedID	0.58
cell type or tissue	0.48

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Histone-lysine N-methyltransferase Smyd1

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Histone-lysine N-methyltransferase Smyd1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.07   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.07   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0