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Tbio
SMYD1
Histone-lysine N-methyltransferase SMYD1

Protein Summary
Description
Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419482
  • ENSP00000393453
  • ENSG00000115593

Symbol
  • BOP
  • KMT3D
  • ZMYND18
  • ZMYND22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
biological process
0.78
microRNA
0.6
PubMedID
0.58
cell type or tissue
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.07   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.07   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (106)
1 – 10 of 106
SCRN3
Tbio
Family:  Enzyme
Novelty:  0.03516382
p_int:  0.999992382
p_ni:  0.000007616
p_wrong:  2e-9
Score:  0.384
Data Source:  BioPlex,STRINGDB
ADSS
Tchem
Family:  Enzyme
Novelty:  0.0126472
p_int:  0.99998102
p_ni:  0.00001898
Score:  0.487
Data Source:  BioPlex,STRINGDB
SPSB3
Tdark
Novelty:  0.07215887
p_int:  0.999973367
p_ni:  0.00002657
p_wrong:  6.3e-8
Score:  0.345
Data Source:  BioPlex,STRINGDB
UNC45B
Tbio
Novelty:  0.01872121
Score:  0.877
Data Source:  STRINGDB
NACA
Tbio
Novelty:  0.08726393
Score:  0.837
Data Source:  STRINGDB
NACA
Tbio
Novelty:  0.08726393
Score:  0.837
Data Source:  STRINGDB
ZNF367
Tbio
Family:  TF
Novelty:  0.27340562
Score:  0.775
Data Source:  STRINGDB
IRX5
Tbio
Family:  TF
Novelty:  0.02583962
Score:  0.751
Data Source:  STRINGDB
HDGF
Tbio
Family:  Epigenetic
Novelty:  0.00273227
Score:  0.738
Data Source:  STRINGDB
UBOX5
Tbio
Novelty:  0.37436118
Score:  0.737
Data Source:  STRINGDB
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
2
2
45.2
alkaline phosphatase measurement
2
1
1
8.4
39.6
serum alanine aminotransferase measurement
1
1
0
5.9
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
45.2
alkaline phosphatase measurement
1
8.4
39.6
serum alanine aminotransferase measurement
0
5.9
30.2
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SET and MYND domain containing 1
VGNC:10766
459386
Macaque
SET and MYND domain containing 1
698950
Mouse
MGI:104790
12180
Rat
RGD:1305105
297333
Dog
SET and MYND domain containing 1
VGNC:46581
475758
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SET and MYND domain containing 1
Macaque
SET and MYND domain containing 1
Mouse
Rat
Dog
SET and MYND domain containing 1
Publication Statistics
PubMed Score 35.07
PubMed score by year
PubTator Score 9.69
PubTator score by year