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Tbio
PRPF38A
Pre-mRNA-splicing factor 38A

Protein Summary
Description
Involved in pre-mRNA splicing as a component of the spliceosome.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257181
  • ENSP00000257181
  • ENSG00000134748

Symbol
  • Prp38
  • PRP38A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
histone modification site profile
0.93
transcription factor perturbation
0.91
drug perturbation
0.71
transcription factor binding site profile
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 38A
VGNC:1471
456858
Macaque
pre-mRNA processing factor 38A
713344
Mouse
MGI:1916962
230596
Rat
RGD:1311129
298374
Dog
pre-mRNA processing factor 38A
VGNC:45022
475350
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 38A
Macaque
pre-mRNA processing factor 38A
Mouse
Rat
Dog
pre-mRNA processing factor 38A
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NAV1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (151)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (283)
1 – 10 of 283
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.999999241
p_ni: 6.8e-8
p_wrong: 6.9e-7
Data Source: BioPlex
MFAP1
Tbio
Novelty: 0.15311456
p_int: 0.999998988
p_ni: 0.000001008
p_wrong: 5e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.999986281
p_ni: 0.000009541
p_wrong: 0.000004178
Data Source: BioPlex
SEC13
Tbio
Novelty: 0.00709413
p_int: 0.996538254
p_ni: 0.003460222
p_wrong: 0.000001525
Score: 0.24
Data Source: BioPlex,STRINGDB
MYORG
Tbio
Family: Enzyme
Novelty: 0.0478246
p_int: 0.966816581
p_ni: 0.000181706
p_wrong: 0.033001714
Score: 0.203
Data Source: BioPlex,STRINGDB
SNRPD3
Tbio
Novelty: 0.02022419
Score: 0.998
Data Source: STRINGDB
PRPF8
Tbio
Novelty: 0.01717158
Score: 0.998
Data Source: STRINGDB
EFTUD2
Tbio
Novelty: 0.01805571
Score: 0.998
Data Source: STRINGDB
SF3B1
Tbio
Novelty: 0.0128965
Score: 0.998
Data Source: STRINGDB
SNU13
Tbio
Novelty: 0.01613497
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.40

PubMed score by year
PubTator Score  2.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer