POMGNT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Protein Summary
O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. This gene encodes a protein with glycosyltransferase activity although its function is not currently known. [provided by RefSeq, Sep 2012]
- ENST00000344697
- ENSP00000344125
- ENSG00000144647
- ENST00000441964
- ENSP00000408992
- AGO61
- C3orf39
- EOGTL
- GTDC2
- AGO61
- GTDC2
- MDDGA8
- MDDGC8
- C3orf39
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.68 | ||
cellular component | 0.63 | ||
histone modification site profile | 0.59 | ||
cell type or tissue | 0.56 | ||
phenotype | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.63 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 147 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.63 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 147 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0