Tbio ZBTB38 Zinc finger and BTB domain-containing protein 38

Protein Summary

Description

Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q8NAP3
• D3DNF6

Gene Name

• ZBTB38

Ensembl ID

• ENST00000321464
• ENSP00000372635
• ENSG00000177311
• ENST00000441582
• ENSP00000406955
• ENST00000514251
• ENSP00000426387
• ENST00000637056
• ENSP00000490041

Symbol

• CIBZ
• ZNF921
• PPP1R171

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.85
protein domain	0.85
ligand (protein) perturbation	0.83
virus perturbation	0.72
molecular function	0.7

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger And Btb Domain-containing Protein 38

Protein / ... / Krab Box Transcription Factor / Zinc Finger And Btb Domain-containing Protein 38

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Zinc Finger And Btb Domain-containing Protein 38

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.98   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.98   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0