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Tbio
ANKLE1
Ankyrin repeat and LEM domain-containing protein 1

Protein Summary
Description
Endonuclease that probably plays a role in the DNA damage response and DNA repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394458
  • ENSP00000377971
  • ENSG00000160117

Symbol
  • ANKRD41
  • LEM3
  • LEM3
  • LEMD6
  • ANKRD41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
protein domain
0.73
hub protein
0.67
cellular component
0.64
transcription factor binding site profile
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.2   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.2   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
96.8
estrogen-receptor negative breast cancer
2
2
0
1.2
88.1
triple-negative breast cancer
1
1
0
1.2
45.4
carrier status
1
1
0
1.2
30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
96.8
estrogen-receptor negative breast cancer
0
1.2
88.1
triple-negative breast cancer
0
1.2
45.4
carrier status
0
1.2
30
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and LEM domain containing 1
VGNC:2091
468765
Macaque
ankyrin repeat and LEM domain containing 1
719709
Mouse
MGI:1918775
234396
Rat
RGD:1308184
361122
Dog
ankyrin repeat and LEM domain containing 1
VGNC:37875
610155
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and LEM domain containing 1
Macaque
ankyrin repeat and LEM domain containing 1
Mouse
Rat
Dog
ankyrin repeat and LEM domain containing 1
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (34)
1 – 10 of 34
LEMD3
Tbio
Novelty: 0.00579701
Score: 0.743
Data Source: STRINGDB
LEXM
Tbio
Novelty: 0.06476414
Score: 0.725
Data Source: STRINGDB
ABHD8
Tdark
Family: Enzyme
Novelty: 0.27752967
Score: 0.723
Data Source: STRINGDB
ANKLE2
Tbio
Novelty: 0.0995907
Score: 0.679
Data Source: STRINGDB
BABAM1
Tbio
Novelty: 0.03812501
Score: 0.674
Data Source: STRINGDB
EMD
Tbio
Novelty: 0.00135202
Score: 0.614
Data Source: STRINGDB
LEMD2
Tbio
Novelty: 0.12460123
Score: 0.609
Data Source: STRINGDB
FGD2
Tdark
Novelty: 0.98876404
Score: 0.564
Data Source: STRINGDB
BANF1
Tbio
Novelty: 0.00092814
Score: 0.561
Data Source: STRINGDB
TMEM30B
Tbio
Novelty: 0.26735006
Score: 0.54
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.20

PubMed score by year
PubTator Score  10.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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