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Tdark
MARCH10
Probable E3 ubiquitin-protein ligase MARCH10

Protein Summary
Description
E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311269
  • ENSP00000311496
  • ENSG00000173838
  • ENST00000456609
  • ENSP00000416177

Symbol
  • RNF190
  • RNF190
  • MARCH-X
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
cell line
0.61
tissue sample
0.52
gene perturbation
0.47
phenotype
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
1
1
1
43.6
neuroticism measurement
1
1
1
40.8
depressive symptom measurement
1
1
1
40.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
1
43.6
neuroticism measurement
1
40.8
depressive symptom measurement
1
40.8
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (25)
1 – 10 of 25
MARCH11
Tbio
Family: Enzyme
Novelty: 0.15289248
Score: 0.732
Data Source: STRINGDB
MARCH9
Tbio
Family: Enzyme
Novelty: 0.19126129
Score: 0.672
Data Source: STRINGDB
MARCH3
Tbio
Family: Enzyme
Novelty: 0.12529817
Score: 0.601
Data Source: STRINGDB
MARCH4
Tdark
Family: Enzyme
Novelty: 0.20869934
Score: 0.601
Data Source: STRINGDB
UNC45A
Tbio
Novelty: 0.07503761
Score: 0.554
Data Source: STRINGDB
EFCAB3
Tdark
Novelty: 0.7941269
Score: 0.547
Data Source: STRINGDB
PRSS48
Tdark
Family: Enzyme
Novelty: 3.46227013
Score: 0.539
Data Source: STRINGDB
UBE2B
Tbio
Novelty: 0.01578275
Score: 0.517
Data Source: STRINGDB
OR11G2
Tdark
Family: oGPCR
Novelty: 10.92587413
Score: 0.489
Data Source: STRINGDB
METTL2A
Tdark
Family: Enzyme
Novelty: 0.72443397
Score: 0.484
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.85

PubMed score by year
PubTator Score  200

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer