Protein Summary
May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways. The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016]
- ENST00000352998
- ENSP00000340132
- ENSG00000188283
- ENST00000589413
- ENSP00000464871
- ENST00000590503
- ENSP00000466101
- HSD17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.58 | ||
tissue sample | 0.58 | ||
tissue | 0.47 | ||
transcription factor | 0.44 | ||
biological process | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.16 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 63 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.16 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 63 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0