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Tdark
TERB1
Telomere repeats-binding bouquet formation protein 1

Protein Summary
Description
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313294
  • ENSP00000464579
  • ENSG00000249961
  • ENST00000433154
  • ENSP00000463762
  • ENST00000558713
  • ENSP00000462883

Symbol
  • CCDC79
  • CCDC79
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (30)
1 – 10 of 30
CCDC155
Tbio
Novelty:  0.16516035
Score:  0.826
Data Source:  STRINGDB
MAJIN
Tdark
Novelty:  0.24903194
Score:  0.802
Data Source:  STRINGDB
TERF1
Tbio
Family:  TF
Novelty:  0.00174529
Score:  0.794
Data Source:  STRINGDB
RAD21L1
Tdark
Novelty:  0.11750397
Score:  0.749
Data Source:  STRINGDB
SUN1
Tbio
Novelty:  0.00931817
Score:  0.705
Data Source:  STRINGDB
ZNF407
Tbio
Family:  TF
Novelty:  0.16936176
Score:  0.692
Data Source:  STRINGDB
TERB2
Tdark
Novelty:  0.39092243
Score:  0.676
Data Source:  STRINGDB
REC8
Tbio
Novelty:  0.00732742
Score:  0.615
Data Source:  STRINGDB
CCDC39
Tbio
Novelty:  0.0150835
Score:  0.605
Data Source:  STRINGDB
USP37
Tbio
Family:  Enzyme
Novelty:  0.05398974
Score:  0.554
Data Source:  STRINGDB
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
2
2
76.1
high density lipoprotein cholesterol measurement
2
2
3
75.1
diastolic blood pressure
1
1
1
73.7
self reported educational attainment
1
1
1
14.2
C-reactive protein measurement
1
1
1
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
76.1
high density lipoprotein cholesterol measurement
3
75.1
diastolic blood pressure
1
73.7
self reported educational attainment
1
14.2
C-reactive protein measurement
1
3.3
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
telomere repeat binding bouquet formation protein 1
VGNC:5702
740520
Mouse
MGI:2443187
320022
Dog
telomere repeat binding bouquet formation protein 1
VGNC:47252
479692
Horse
telomere repeat binding bouquet formation protein 1
VGNC:51341
100629543
Cow
telomere repeat binding bouquet formation protein 1
VGNC:35748
100295202
Species
Name
OMA
EggNOG
Inparanoid
Chimp
telomere repeat binding bouquet formation protein 1
Mouse
Dog
telomere repeat binding bouquet formation protein 1
Horse
telomere repeat binding bouquet formation protein 1
Cow
telomere repeat binding bouquet formation protein 1
Publication Statistics
PubMed Score 5.94
PubMed score by year
PubTator Score 1.79
PubTator score by year