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Tbio
L3MBTL4
Lethal(3)malignant brain tumor-like protein 4

Protein Summary
Description
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400104
  • ENSP00000382975
  • ENSG00000154655
  • ENST00000400105
  • ENSP00000382976

Symbol
  • HsT1031
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
virus perturbation
0.68
trait
0.61
cell line
0.57
tissue sample
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.37   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.37   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
53.8
refractive error measurement
1
1
1
8.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
53.8
refractive error measurement
1
8.6
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
L3MBTL4, histone methyl-lysine binding protein
707460
Mouse
MGI:2444889
320858
Dog
L3MBTL4, histone methyl-lysine binding protein
VGNC:50636
490541
Opossum
L3MBTL4, histone methyl-lysine binding protein
100015771
Species
Name
OMA
EggNOG
Inparanoid
Macaque
L3MBTL4, histone methyl-lysine binding protein
Mouse
Dog
L3MBTL4, histone methyl-lysine binding protein
Opossum
L3MBTL4, histone methyl-lysine binding protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NA19-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (46)
1 – 10 of 46
CCDC178
Tdark
Novelty: 0.59356582
Score: 0.755
Data Source: STRINGDB
CCDC102B
Tdark
Novelty: 0.28075569
Score: 0.725
Data Source: STRINGDB
FOXRED1
Tbio
Family: Enzyme
Novelty: 0.07057772
Score: 0.723
Data Source: STRINGDB
RTTN
Tbio
Novelty: 0.04524944
Score: 0.714
Data Source: STRINGDB
GATB
Tbio
Family: Enzyme
Novelty: 0.01269151
Score: 0.709
Data Source: STRINGDB
TDRD12
Tdark
Family: Epigenetic
Novelty: 0.2276017
Score: 0.695
Data Source: STRINGDB
TDRD3
Tbio
Family: Epigenetic
Novelty: 0.07637876
Score: 0.687
Data Source: STRINGDB
TDRKH
Tbio
Family: Epigenetic
Novelty: 0.0875409
Score: 0.685
Data Source: STRINGDB
GPRC5B
Tbio
Family: GPCR
Novelty: 0.05128765
Score: 0.682
Data Source: STRINGDB
DTNA
Tbio
Novelty: 0.01165754
Score: 0.665
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.37

PubMed score by year
PubTator Score  2.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer