Tbio FSIP1 Fibrous sheath-interacting protein 1

Protein Summary

Uniprot Accession IDs

• Q8NA03
• Q6X2C8
• Q86Y89

Gene Name

• FSIP1

Ensembl ID

• ENST00000350221
• ENSP00000280236
• ENSG00000150667

Symbol

• HSD10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.66
disease perturbation	0.62
trait	0.61
transcription factor binding site profile	0.55
cell line	0.5

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.97   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.97   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cortical surface area measurement	EFO_0010736	1	1	0	8.5	70.1
urate measurement	EFO_0004531	1	1	2		64.7
serum gamma-glutamyl transferase measurement	EFO_0004532	1	1	1		6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cortical surface area measurement	EFO_0010736	0	8.5	70.1
urate measurement	EFO_0004531	2		64.7
serum gamma-glutamyl transferase measurement	EFO_0004532	1		6

Reset Zoom  Beta Count   Odds Ratio

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	fibrous sheath interacting protein 1	VGNC:3552	737356
Macaque	fibrous sheath interacting protein 1		701001
Mouse	fibrous sheath-interacting protein 1	MGI:1918563	71313
Rat	fibrous sheath interacting protein 1	RGD:1306874	296074
Dog	fibrous sheath interacting protein 1	VGNC:40998	478256

Species	Name	OMA	EggNOG	Inparanoid
Chimp	fibrous sheath interacting protein 1
Macaque	fibrous sheath interacting protein 1
Mouse	fibrous sheath-interacting protein 1
Rat	fibrous sheath interacting protein 1
Dog	fibrous sheath interacting protein 1

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8NA03-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (61)

Explore Interacting Targets

1 – 10 of 61

• See Interactions on String-DB

HSD17B10

Tchem

Family: Enzyme

Novelty: 0.00486582

Score: 0.834

Data Source: STRINGDB

AKAP4

Tbio

Family: Enzyme

Novelty: 0.00760557

Score: 0.818

Data Source: STRINGDB

FSIP2

Tdark

Novelty: 0.16245939

Score: 0.81

Data Source: STRINGDB

DHRS11

Tbio

Family: Enzyme

Novelty: 0.00352776

Score: 0.757

Data Source: STRINGDB

TRMT10C

Tbio

Family: Enzyme

Novelty: 0.07045719

Score: 0.71

Data Source: STRINGDB

KIAA0391

Tbio

Family: Enzyme

Novelty: 0.02276396

Score: 0.669

Data Source: STRINGDB

AKAP3

Tbio

Family: Enzyme

Novelty: 0.030936

Score: 0.66

Data Source: STRINGDB

RIBC1

Tdark

Novelty: 0.40435429

Score: 0.655

Data Source: STRINGDB

HADH

Tbio

Family: Enzyme

Novelty: 0.00368073

Score: 0.63

Data Source: STRINGDB

ROPN1

Tbio

Novelty: 0.05375245

Score: 0.607

Data Source: STRINGDB

Publication Statistics

PubMed Score  51.97

PubMed score by year

Reset Zoom

PubTator Score  22.9

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

Coiled coil
Complete proteome
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

cortical surface area measurement
serum gamma-glutamyl transferase measurement
urate measurement