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Tbio
BOLL
Protein boule-like

Protein Summary
Description
Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282278
  • ENSP00000282278
  • ENSG00000152430
  • ENST00000321801
  • ENSP00000314792
  • ENST00000392296
  • ENSP00000376116
  • ENST00000433157
  • ENSP00000396099

Symbol
  • BOULE
  • BOULE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
microRNA
0.69
histone modification site profile
0.65
cell type or tissue
0.57
PubMedID
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.48   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 440   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.48   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 440   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
CDC20B
Tbio
Novelty:  0.15800256
p_int:  0.997984053
p_ni:  0.001992382
p_wrong:  0.000023565
Score:  0.87
Data Source:  BioPlex,STRINGDB
UBA5
Tbio
Novelty:  0.05089296
p_int:  0.988448148
p_ni:  0.011551851
p_wrong:  1e-9
Score:  0.865
Data Source:  BioPlex,STRINGDB
ACY1
Tbio
Family:  Enzyme
Novelty:  0.00912344
p_int:  0.902165021
p_ni:  0.097834979
Score:  0.29
Data Source:  BioPlex,STRINGDB
CPEB1
Tbio
Novelty:  0.00444378
Score:  0.912
Data Source:  STRINGDB
CDC25A
Tchem
Family:  Enzyme
Novelty:  0.00250149
Score:  0.816
Data Source:  STRINGDB
DAZAP2
Tbio
Novelty:  0.02387823
Score:  0.8
Data Source:  STRINGDB
DDX4
Tbio
Family:  Enzyme
Novelty:  0.00692586
Score:  0.723
Data Source:  STRINGDB
PUM2
Tbio
Novelty:  0.01849765
Score:  0.689
Data Source:  STRINGDB
KPNA2
Tbio
Novelty:  0.00506958
Score:  0.652
Data Source:  STRINGDB
SYCP3
Tbio
Novelty:  0.00443901
Score:  0.652
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
2
0
1
81.6
body mass index
2
2
2
66.6
body fat distribution
2
1
2
45.7
waist circumference
1
2
2
43.9
BMI-adjusted waist circumference
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
81.6
body mass index
2
66.6
body fat distribution
2
45.7
waist circumference
2
43.9
BMI-adjusted waist circumference
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
boule homolog, RNA binding protein
VGNC:106
459855
Macaque
boule homolog, RNA binding protein
698402
Mouse
MGI:1922638
75388
Rat
RGD:11425682
108348134
Dog
boule homolog, RNA binding protein
VGNC:38497
488458
Species
Name
OMA
EggNOG
Inparanoid
Chimp
boule homolog, RNA binding protein
Macaque
boule homolog, RNA binding protein
Mouse
Rat
Dog
boule homolog, RNA binding protein
Publication Statistics
PubMed Score 54.48
PubMed score by year
PubTator Score 69.87
PubTator score by year
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Related Publications
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PMID
Year
Title