Tbio BOLL Protein boule-like

Protein Summary

Description

Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N9W6
• B4DZA4
• Q0JW32
• Q53T62
• Q969U3

Gene Name

• BOLL

Ensembl ID

• ENST00000282278
• ENSP00000282278
• ENSG00000152430
• ENST00000321801
• ENSP00000314792
• ENST00000392296
• ENSP00000376116
• ENST00000433157
• ENSP00000396099

Symbol

• BOULE
• BOULE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
microRNA	0.69
histone modification site profile	0.65
cell type or tissue	0.57
PubMedID	0.56

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Protein Boule-like

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Protein Boule-like

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.48   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 440   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.48   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 440   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (76)

Explore Interacting Targets

1 – 10 of 76

• See Interactions on String-DB

CDC20B

Tbio

Novelty:  0.15800256

p_int:  0.997984053

p_ni:  0.001992382

p_wrong:  0.000023565

Score:  0.87

Data Source:  BioPlex,STRINGDB

UBA5

Tbio

Novelty:  0.05089296

p_int:  0.988448148

p_ni:  0.011551851

p_wrong:  1e-9

Score:  0.865

Data Source:  BioPlex,STRINGDB

ACY1

Tbio

Family:  Enzyme

Novelty:  0.00912344

p_int:  0.902165021

p_ni:  0.097834979

Score:  0.29

Data Source:  BioPlex,STRINGDB

CPEB1

Tbio

Novelty:  0.00444378

Score:  0.912

Data Source:  STRINGDB

CDC25A

Tchem

Family:  Enzyme

Novelty:  0.00250149

Score:  0.816

Data Source:  STRINGDB

DAZAP2

Tbio

Novelty:  0.02387823

Score:  0.8

Data Source:  STRINGDB

DDX4

Tbio

Family:  Enzyme

Novelty:  0.00692586

Score:  0.723

Data Source:  STRINGDB

PUM2

Tbio

Novelty:  0.01849765

Score:  0.689

Data Source:  STRINGDB

KPNA2

Tbio

Novelty:  0.00506958

Score:  0.652

Data Source:  STRINGDB

SYCP3

Tbio

Novelty:  0.00443901

Score:  0.652

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (2)

Components (1)

Processes (5)

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GO Term	Evidence	Assigned by
translation activator activity	Inferred from Direct Assay (IDA)	UniProtKB
mRNA 3'-UTR binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (7)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	1	2	0	1	81.6
body mass index	EFO_0004340	2	2	2		66.6
body fat distribution	EFO_0004341	2	1	2		45.7
waist circumference	EFO_0004342	1	2	2		43.9
BMI-adjusted waist circumference	EFO_0007789	1	1	1		36.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	0	1	81.6
body mass index	EFO_0004340	2		66.6
body fat distribution	EFO_0004341	2		45.7
waist circumference	EFO_0004342	2		43.9
BMI-adjusted waist circumference	EFO_0007789	1		36.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Reference proteome
RNA-binding
Spermatogenesis
Translation regulation

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
body fat distribution
body mass index
brain aneurysm
chronotype measurement
rheumatoid arthritis
waist circumference

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	boule homolog, RNA binding protein	VGNC:106	459855
Macaque	boule homolog, RNA binding protein		698402
Mouse	boule homolog, RNA binding protein	MGI:1922638	75388
Rat	protein boule-like	RGD:11425682	108348134
Dog	boule homolog, RNA binding protein	VGNC:38497	488458

Species	Name	OMA	EggNOG	Inparanoid
Chimp	boule homolog, RNA binding protein
Macaque	boule homolog, RNA binding protein
Mouse	boule homolog, RNA binding protein
Rat	protein boule-like
Dog	boule homolog, RNA binding protein

Publication Statistics

PubMed Score 54.48

PubMed score by year

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PubTator Score 69.87

PubTator score by year

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Related Publications

Text Mined References (26)

GeneRif Annotations (16)

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PMID	Year	Title