DNAAF3
Dynein assembly factor 3, axonemal
Protein Summary
Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia. The protein encoded by this gene is required for the assembly of axonemal inner and outer dynein arms and plays a role in assembling dynein complexes for transport into cilia. Defects in this gene are a cause of primary ciliary dyskinesia type 2 (CILD2). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
- ENST00000391720
- ENSP00000375600
- ENSG00000167646
- ENST00000455045
- ENSP00000394343
- ENST00000524407
- ENSP00000432046
- ENST00000527223
- ENSP00000436975
- ENST00000528412
- ENSP00000433826
- ENST00000534214
- ENSP00000433247
- C19orf51
- PCD
- DAB1
- PF22
- CILD2
- C19orf51
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.73 | ||
tissue sample | 0.73 | ||
cell type or tissue | 0.63 | ||
transcription factor binding site profile | 0.57 | ||
tissue | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.94 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.94 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0