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Tdark
TRIML1
Probable E3 ubiquitin-protein ligase TRIML1

Protein Summary
Description
Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development. The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332517
  • ENSP00000327738
  • ENSG00000184108

Symbol
  • RNF209
  • RNF209
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
protein domain
0.97
cell type or tissue
0.72
cellular component
0.64
cell line
0.56


Related Tools
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif family like 1
471383
Macaque
tripartite motif family like 1
698114
Mouse
MGI:2687279
244448
Rat
RGD:1305337
290767
Dog
tripartite motif family like 1
VGNC:47841
475619
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif family like 1
Macaque
tripartite motif family like 1
Mouse
Rat
Dog
tripartite motif family like 1
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (38)
1 – 10 of 38
ZSWIM2
Tbio
Family: Enzyme
Novelty: 0.02135835
Score: 0.693
Data Source: STRINGDB
FANCD2OS
Tdark
Novelty: 9.51798561
Score: 0.687
Data Source: STRINGDB
ATP10D
Tdark
Family: Transporter
Novelty: 0.21272192
Score: 0.646
Data Source: STRINGDB
BEND5
Tdark
Novelty: 0.6502216
Score: 0.641
Data Source: STRINGDB
CCT6B
Tdark
Novelty: 0.28933315
Score: 0.615
Data Source: STRINGDB
CCIN
Tbio
Novelty: 0.05318622
Score: 0.588
Data Source: STRINGDB
DPEP2
Tbio
Family: Enzyme
Novelty: 0.14691384
Score: 0.588
Data Source: STRINGDB
ADAM29
Tbio
Family: Enzyme
Novelty: 0.09044262
Score: 0.587
Data Source: STRINGDB
SCFD2
Tdark
Novelty: 0.38252131
Score: 0.566
Data Source: STRINGDB
FRG1
Tbio
Novelty: 0.0292811
Score: 0.562
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.84

PubMed score by year
PubTator Score  0.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer