Tbio BANP Protein BANP

Protein Summary

Description

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity). This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q8N9N5
• A8MU25
• A8MX25
• B2RCF7
• B4DNJ9
• F5GZM0
• Q96GJ7
• Q9NWY1

Gene Name

• BANP

Ensembl ID

• ENST00000286122
• ENSP00000286122
• ENSG00000172530
• ENST00000355022
• ENSP00000347125
• ENST00000393207
• ENSP00000376902
• ENST00000393208
• ENSP00000376903
• ENST00000479780
• ENSP00000432508
• ENST00000538234
• ENSP00000444352
• ENST00000626016
• ENSP00000487304

Symbol

• BEND1
• SMAR1
• BEND1
• SMAR1
• SMARBP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
transcription factor binding site profile	0.97
transcription factor	0.79
cell type or tissue	0.77
tissue sample	0.64

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.52   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.52   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

BRK1

Tbio

Novelty:  0.02289534

p_int:  0.999999516

p_ni:  4.83e-7

p_wrong:  1e-9

Data Source:  BioPlex

VMAC

Tdark

Novelty:  0.83333333

p_int:  0.999985686

p_ni:  0.00001431

p_wrong:  4e-9

Score:  0.252

Data Source:  BioPlex,STRINGDB

FAM9C

Tdark

Novelty:  0.86727989

p_int:  0.99997829

p_ni:  0.00002171

Data Source:  BioPlex

WASHC3

Tdark

Novelty:  0.18307321

p_int:  0.999976603

p_ni:  0.000023396

Data Source:  BioPlex

NGRN

Tbio

Novelty:  0.11162143

p_int:  0.999967463

p_ni:  0.000032537

Data Source:  BioPlex

TROAP

Tbio

Novelty:  0.06268103

p_int:  0.999638942

p_ni:  0.000358081

p_wrong:  0.000002978

Data Source:  BioPlex

HEXIM2

Tbio

Novelty:  0.14814693

p_int:  0.999503702

p_ni:  0.000496265

p_wrong:  3.3e-8

Score:  0.206

Data Source:  BioPlex,STRINGDB

PDHB

Tbio

Family:  Enzyme

Novelty:  0.01018086

p_int:  0.999364756

p_ni:  0.000634348

p_wrong:  8.96e-7

Data Source:  BioPlex

MATN2

Tbio

Novelty:  0.08506252

p_int:  0.999349474

p_ni:  0.000650525

Data Source:  BioPlex

CPSF4L

Tdark

Novelty:  4.27116708

p_int:  0.997940961

p_ni:  0.00205901

p_wrong:  2.9e-8

Score:  0.222

Data Source:  BioPlex,STRINGDB

Pathways (6)

Reactome (6)

Gene expression (Transcription) (R-HSA-74160)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	Regulation of TP53 Activity	160 targets	R-HSA-5633007
Reactome	Regulation of TP53 Activity through Association with Co-factors	14 targets	R-HSA-6804759

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Regulation of TP53 Activity	160 targets	R-HSA-5633007
Regulation of TP53 Activity through Association with Co-factors	14 targets	R-HSA-6804759

Gene Ontology Terms (12)

Functions (3)

Components (2)

Processes (7)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
p53 binding	Inferred from Electronic Annotation (IEA)	Ensembl

GWAS Traits (18)

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1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1	2	2		93.7
mean reticulocyte volume	EFO_0010701	1	1	1		86.3
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		84.9
platelet count	EFO_0004309	1	2	2		83
sex hormone-binding globulin measurement	EFO_0004696	6	1	6		81.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	2		93.7
mean reticulocyte volume	EFO_0010701	1		86.3
mean corpuscular hemoglobin concentration	EFO_0004528	1		84.9
platelet count	EFO_0004309	2		83
sex hormone-binding globulin measurement	EFO_0004696	6		81.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Cell cycle
Chromatin regulator
Coiled coil
Complete proteome
Developmental protein
DNA-binding
Isopeptide bond
Nucleus

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
basophil count
basophil percentage of granulocytes
basophil percentage of leukocytes
high density lipoprotein cholesterol measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume
neutrophil percentage of leukocytes
platelet count

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	BTG3 associated nuclear protein	VGNC:13669	454354
Macaque	BTG3 associated nuclear protein		696125
Mouse	BTG3 associated nuclear protein	MGI:1889023	53325
Rat	Btg3 associated nuclear protein	RGD:1307464	292064
Dog	BTG3 associated nuclear protein	VGNC:38378	479618

Species	Name	OMA	EggNOG	Inparanoid
Chimp	BTG3 associated nuclear protein
Macaque	BTG3 associated nuclear protein
Mouse	BTG3 associated nuclear protein
Rat	Btg3 associated nuclear protein
Dog	BTG3 associated nuclear protein

Publication Statistics

PubMed Score 59.52

PubMed score by year

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PubTator Score 22.22

PubTator score by year

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