Protein Summary
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity). This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
- ENST00000286122
- ENSP00000286122
- ENSG00000172530
- ENST00000355022
- ENSP00000347125
- ENST00000393207
- ENSP00000376902
- ENST00000393208
- ENSP00000376903
- ENST00000479780
- ENSP00000432508
- ENST00000538234
- ENSP00000444352
- ENST00000626016
- ENSP00000487304
- BEND1
- SMAR1
- BEND1
- SMAR1
- SMARBP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.97 | ||
transcription factor binding site profile | 0.97 | ||
transcription factor | 0.79 | ||
cell type or tissue | 0.77 | ||
tissue sample | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 59.52 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 125 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 59.52 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 125 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (68)
VMAC
Novelty: 0.83333333
p_int: 0.999985686
p_ni: 0.00001431
p_wrong: 4e-9
Score: 0.252
Data Source: BioPlex,STRINGDB
TROAP
Novelty: 0.06268103
p_int: 0.999638942
p_ni: 0.000358081
p_wrong: 0.000002978
Data Source: BioPlex
HEXIM2
Novelty: 0.14814693
p_int: 0.999503702
p_ni: 0.000496265
p_wrong: 3.3e-8
Score: 0.206
Data Source: BioPlex,STRINGDB
PDHB
Family: Enzyme
Novelty: 0.01018086
p_int: 0.999364756
p_ni: 0.000634348
p_wrong: 8.96e-7
Data Source: BioPlex
CPSF4L
Novelty: 4.27116708
p_int: 0.997940961
p_ni: 0.00205901
p_wrong: 2.9e-8
Score: 0.222
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | Regulation of TP53 Activity | ||||
Reactome | Regulation of TP53 Activity through Association with Co-factors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
Regulation of TP53 Activity | ||||
Regulation of TP53 Activity through Association with Co-factors | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (2)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 2 | 2 | 93.7 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 86.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 84.9 | |||||
platelet count | 1 | 2 | 2 | 83 | |||||
sex hormone-binding globulin measurement | 6 | 1 | 6 | 81.7 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular volume | 2 | 93.7 | |||||
mean reticulocyte volume | 1 | 86.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 84.9 | |||||
platelet count | 2 | 83 | |||||
sex hormone-binding globulin measurement | 6 | 81.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | BTG3 associated nuclear protein | VGNC:13669 | 454354 | |||||
Macaque | BTG3 associated nuclear protein | 696125 | ||||||
Mouse | MGI:1889023 | 53325 | ||||||
Rat | RGD:1307464 | 292064 | ||||||
Dog | BTG3 associated nuclear protein | VGNC:38378 | 479618 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | BTG3 associated nuclear protein | |||||
Macaque | BTG3 associated nuclear protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | BTG3 associated nuclear protein | |||||
Publication Statistics
PubMed Score 59.52
PubMed score by year
PubTator Score 22.22
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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