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Tbio
ASCC1
Activating signal cointegrator 1 complex subunit 1

Protein Summary
Description
Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have bee ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317126
  • ENSP00000320461
  • ENSG00000138303
  • ENST00000317168
  • ENSP00000320810
  • ENST00000342444
  • ENSP00000339404
  • ENST00000394915
  • ENSP00000378373
  • ENST00000394919
  • ENSP00000378377

Symbol
  • p50
  • CGI-18
  • SMABF2
  • ASC1p50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
histone modification site profile
0.77
protein domain
0.73
transcription factor binding site profile
0.68
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.76   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.76   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
ASCC2
Tbio
Novelty:  0.12261896
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
TRIP4
Tbio
Novelty:  0.06089355
p_int:  0.99999999
p_ni:  2e-9
p_wrong:  9e-9
Score:  0.964
Data Source:  BioPlex,STRINGDB
ASCC3
Tbio
Novelty:  0.1303631
p_int:  0.999998287
p_ni:  0.000001713
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
FGG
Tbio
Novelty:  0.00404457
p_int:  0.999498504
p_ni:  0.000477644
p_wrong:  0.000023852
Score:  0.204
Data Source:  BioPlex,STRINGDB
IGHG2
Tclin
p_int:  0.998365438
p_ni:  0.001632569
p_wrong:  0.000001993
Data Source:  BioPlex
FGB
Tbio
Novelty:  0.00437751
p_int:  0.995599086
p_ni:  0.0043941
p_wrong:  0.000006814
Score:  0.204
Data Source:  BioPlex,STRINGDB
IGHG1
Tclin
p_int:  0.995059549
p_ni:  0.004940451
Data Source:  BioPlex
C3
Tclin
Novelty:  0.00019115
p_int:  0.993149962
p_ni:  0.006849953
p_wrong:  8.5e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
IGKC
Tdark
p_int:  0.988787785
p_ni:  0.011212152
p_wrong:  6.3e-8
Data Source:  BioPlex
CPA4
Tchem
Family:  Enzyme
Novelty:  0.01439845
p_int:  0.932122089
p_ni:  0.067877911
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
ALKBH3 mediated reversal of alkylation damage (R-HSA-112126)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ALKBH3 mediated reversal of alkylation damage
Reactome
DNA Damage Reversal
Reactome
DNA Repair
Reactome
Reversal of alkylation damage by DNA dioxygenases
Name
Explore in Pharos
Explore in Source
ALKBH3 mediated reversal of alkylation damage
DNA Damage Reversal
DNA Repair
Reversal of alkylation damage by DNA dioxygenases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
59.6
1
1
1
14.2
hair color
1
1
0
1.1
7.8
refractive error measurement
1
1
1
5.4
1
1
0
1.2
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
59.6
1
14.2
hair color
0
1.1
7.8
refractive error measurement
1
5.4
0
1.2
1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activating signal cointegrator 1 complex subunit 1
VGNC:3811
450519
Macaque
activating signal cointegrator 1 complex subunit 1
709049
Mouse
MGI:1916340
69090
Rat
RGD:1359255
294512
Dog
activating signal cointegrator 1 complex subunit 1
VGNC:38170
608331
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activating signal cointegrator 1 complex subunit 1
Macaque
activating signal cointegrator 1 complex subunit 1
Mouse
Rat
Dog
activating signal cointegrator 1 complex subunit 1
Publication Statistics
PubMed Score 9.76
PubMed score by year
PubTator Score 102.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title