Tbio ASCC1 Activating signal cointegrator 1 complex subunit 1

Protein Summary

Description

Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q8N9N2
• Q5SW06
• Q5SW07
• Q96EI8
• Q9Y307

Gene Name

• ASCC1

Ensembl ID

• ENST00000317126
• ENSP00000320461
• ENSG00000138303
• ENST00000317168
• ENSP00000320810
• ENST00000342444
• ENSP00000339404
• ENST00000394915
• ENSP00000378373
• ENST00000394919
• ENSP00000378377

Symbol

• p50
• CGI-18
• SMABF2
• ASC1p50

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
histone modification site profile	0.77
protein domain	0.73
transcription factor binding site profile	0.68
kinase perturbation	0.66

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.76   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.76   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Protein-Protein Interactions (42)

Explore Interacting Targets

1 – 10 of 42

• See Interactions on String-DB

ASCC2

Tbio

Novelty:  0.12261896

p_int:  1

Score:  0.995

Data Source:  BioPlex,Reactome,STRINGDB

TRIP4

Tbio

Novelty:  0.06089355

p_int:  0.99999999

p_ni:  2e-9

p_wrong:  9e-9

Score:  0.964

Data Source:  BioPlex,STRINGDB

ASCC3

Tbio

Novelty:  0.1303631

p_int:  0.999998287

p_ni:  0.000001713

Score:  0.992

Data Source:  BioPlex,Reactome,STRINGDB

FGG

Tbio

Novelty:  0.00404457

p_int:  0.999498504

p_ni:  0.000477644

p_wrong:  0.000023852

Score:  0.204

Data Source:  BioPlex,STRINGDB

IGHG2

Tclin

p_int:  0.998365438

p_ni:  0.001632569

p_wrong:  0.000001993

Data Source:  BioPlex

FGB

Tbio

Novelty:  0.00437751

p_int:  0.995599086

p_ni:  0.0043941

p_wrong:  0.000006814

Score:  0.204

Data Source:  BioPlex,STRINGDB

IGHG1

Tclin

p_int:  0.995059549

p_ni:  0.004940451

Data Source:  BioPlex

C3

Tclin

Novelty:  0.00019115

p_int:  0.993149962

p_ni:  0.006849953

p_wrong:  8.5e-8

Score:  0.211

Data Source:  BioPlex,STRINGDB

IGKC

Tdark

p_int:  0.988787785

p_ni:  0.011212152

p_wrong:  6.3e-8

Data Source:  BioPlex

CPA4

Tchem

Family:  Enzyme

Novelty:  0.01439845

p_int:  0.932122089

p_ni:  0.067877911

Score:  0.161

Data Source:  BioPlex,STRINGDB

Pathways (4)

Reactome (4)

ALKBH3 mediated reversal of alkylation damage (R-HSA-112126)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ALKBH3 mediated reversal of alkylation damage	4 targets	R-HSA-112126
Reactome	DNA Damage Reversal	8 targets	R-HSA-73942
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Reversal of alkylation damage by DNA dioxygenases	7 targets	R-HSA-73943

Name	Explore in Pharos	Explore in Source
ALKBH3 mediated reversal of alkylation damage	4 targets	R-HSA-112126
DNA Damage Reversal	8 targets	R-HSA-73942
DNA Repair	306 targets	R-HSA-73894
Reversal of alkylation damage by DNA dioxygenases	7 targets	R-HSA-73943

Gene Ontology Terms (8)

Functions (1)

Components (5)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from Electronic Annotation (IEA)	InterPro

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		59.6
type II diabetes mellitus	EFO_0001360	1	1	1		14.2
hair color	EFO_0003924	1	1	0	1.1	7.8
refractive error measurement	EFO_0007814	1	1	1		5.4
lumbar disc degeneration	EFO_0004994	1	1	0	1.2	1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		59.6
type II diabetes mellitus	EFO_0001360	1		14.2
hair color	EFO_0003924	0	1.1	7.8
refractive error measurement	EFO_0007814	1		5.4
lumbar disc degeneration	EFO_0004994	0	1.2	1

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Direct protein sequencing
DNA damage
DNA repair
Neurodegeneration
Nucleus
Polymorphism
Reference proteome
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
body height
hair color
lumbar disc degeneration
refractive error measurement
type II diabetes mellitus

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	activating signal cointegrator 1 complex subunit 1	VGNC:3811	450519
Macaque	activating signal cointegrator 1 complex subunit 1		709049
Mouse	activating signal cointegrator 1 complex subunit 1	MGI:1916340	69090
Rat	activating signal cointegrator 1 complex subunit 1	RGD:1359255	294512
Dog	activating signal cointegrator 1 complex subunit 1	VGNC:38170	608331

Species	Name	OMA	EggNOG	Inparanoid
Chimp	activating signal cointegrator 1 complex subunit 1
Macaque	activating signal cointegrator 1 complex subunit 1
Mouse	activating signal cointegrator 1 complex subunit 1
Rat	activating signal cointegrator 1 complex subunit 1
Dog	activating signal cointegrator 1 complex subunit 1

Publication Statistics

PubMed Score 9.76

PubMed score by year

Reset Zoom

PubTator Score 102.00

PubTator score by year

Reset Zoom