ASCC1
Activating signal cointegrator 1 complex subunit 1
Protein Summary
Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have bee ...more
- ENST00000317126
- ENSP00000320461
- ENSG00000138303
- ENST00000317168
- ENSP00000320810
- ENST00000342444
- ENSP00000339404
- ENST00000394915
- ENSP00000378373
- ENST00000394919
- ENSP00000378377
- p50
- CGI-18
- SMABF2
- ASC1p50
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.87 | ||
histone modification site profile | 0.77 | ||
protein domain | 0.73 | ||
transcription factor binding site profile | 0.68 | ||
kinase perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.76 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 159 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.76 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 159 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (42)
TRIP4
Novelty: 0.06089355
p_int: 0.99999999
p_ni: 2e-9
p_wrong: 9e-9
Score: 0.964
Data Source: BioPlex,STRINGDB
ASCC3
Novelty: 0.1303631
p_int: 0.999998287
p_ni: 0.000001713
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
FGG
Novelty: 0.00404457
p_int: 0.999498504
p_ni: 0.000477644
p_wrong: 0.000023852
Score: 0.204
Data Source: BioPlex,STRINGDB
FGB
Novelty: 0.00437751
p_int: 0.995599086
p_ni: 0.0043941
p_wrong: 0.000006814
Score: 0.204
Data Source: BioPlex,STRINGDB
C3
Novelty: 0.00019115
p_int: 0.993149962
p_ni: 0.006849953
p_wrong: 8.5e-8
Score: 0.211
Data Source: BioPlex,STRINGDB
CPA4
Family: Enzyme
Novelty: 0.01439845
p_int: 0.932122089
p_ni: 0.067877911
Score: 0.161
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ALKBH3 mediated reversal of alkylation damage | ||||
Reactome | DNA Damage Reversal | ||||
Reactome | DNA Repair | ||||
Reactome | Reversal of alkylation damage by DNA dioxygenases | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ALKBH3 mediated reversal of alkylation damage | ||||
DNA Damage Reversal | ||||
DNA Repair | ||||
Reversal of alkylation damage by DNA dioxygenases | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 59.6 | |||||
1 | 1 | 1 | 14.2 | ||||||
hair color | 1 | 1 | 0 | 1.1 | 7.8 | ||||
refractive error measurement | 1 | 1 | 1 | 5.4 | |||||
1 | 1 | 0 | 1.2 | 1 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 59.6 | |||||
1 | 14.2 | ||||||
hair color | 0 | 1.1 | 7.8 | ||||
refractive error measurement | 1 | 5.4 | |||||
0 | 1.2 | 1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | activating signal cointegrator 1 complex subunit 1 | VGNC:3811 | 450519 | |||||
Macaque | activating signal cointegrator 1 complex subunit 1 | 709049 | ||||||
Mouse | MGI:1916340 | 69090 | ||||||
Rat | RGD:1359255 | 294512 | ||||||
Dog | activating signal cointegrator 1 complex subunit 1 | VGNC:38170 | 608331 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | activating signal cointegrator 1 complex subunit 1 | |||||
Macaque | activating signal cointegrator 1 complex subunit 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | activating signal cointegrator 1 complex subunit 1 | |||||
Publication Statistics
PubMed Score 9.76
PubMed score by year
PubTator Score 102.00
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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