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Tbio
ACOT4
Acyl-coenzyme A thioesterase 4

Protein Summary
Description
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326303
  • ENSP00000323071
  • ENSG00000177465

Symbol
  • PTE2B
  • PTEIB
  • PTE1B
  • PTE2B
  • PTE-Ib
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.73
disease
0.72
protein domain
0.58
tissue sample
0.53
pathway
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.99   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.99   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Beta-oxidation of very long chain fatty acids (R-HSA-390247)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of very long chain fatty acids
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (79)
1 – 10 of 79
EHHADH
Tbio
Novelty: 0.00763197
Score: 0.98
Data Source: STRINGDB
LONP2
Tbio
Family: Enzyme
Novelty: 0.06368768
Score: 0.965
Data Source: STRINGDB
ACOT8
Tbio
Family: Enzyme
Novelty: 0.00367339
Score: 0.963
Data Source: STRINGDB
ECH1
Tbio
Family: Enzyme
Novelty: 0.04455822
Score: 0.961
Data Source: STRINGDB
PECR
Tbio
Family: Enzyme
Novelty: 0.01991654
Score: 0.958
Data Source: STRINGDB
ACOX2
Tbio
Family: Enzyme
Novelty: 0.05104162
Score: 0.957
Data Source: STRINGDB
HAO2
Tchem
Family: Enzyme
Novelty: 0.05085077
Score: 0.956
Data Source: STRINGDB
CROT
Tbio
Family: Enzyme
Novelty: 0.04628118
Score: 0.952
Data Source: STRINGDB
PIPOX
Tbio
Family: Enzyme
Novelty: 0.00144303
Score: 0.951
Data Source: STRINGDB
GNPAT
Tchem
Family: Enzyme
Novelty: 0.0152005
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.99

PubMed score by year
PubTator Score  1.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer