Tbio ACOT4 Acyl-coenzyme A thioesterase 4

Protein Summary

Description

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.

Uniprot Accession IDs

• Q8N9L9
• Q17RF4
• Q5BKT6
• Q86TX0
• Q86TX1
• Q96N88
• Acyl-CoA thioesterase 4

Gene Name

• ACOT4

Ensembl ID

• ENST00000326303
• ENSP00000323071
• ENSG00000177465

Symbol

• PTE2B
• PTEIB
• PTE1B
• PTE2B
• PTE-Ib

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.73
disease	0.72
protein domain	0.58
tissue sample	0.53
pathway	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 74   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0