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Tbio
DTX3
Probable E3 ubiquitin-protein ligase DTX3

Protein Summary
Description
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337737
  • ENSP00000338050
  • ENSG00000178498
  • ENST00000548198
  • ENSP00000447873
  • ENST00000548804
  • ENSP00000449294
  • ENST00000551632
  • ENSP00000448696

Symbol
  • RNF154
  • RNF154
  • deltex3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor perturbation
0.74
cell line
0.6
kinase perturbation
0.6
tissue
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.88   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.88   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
2
2
80.9
1
1
0
1.4
56.4
body fat distribution
1
1
2
31.4
IGF-1 measurement
1
1
1
30.2
systolic blood pressure
1
1
1
29.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
80.9
0
1.4
56.4
body fat distribution
2
31.4
IGF-1 measurement
1
30.2
systolic blood pressure
1
29.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deltex E3 ubiquitin ligase 3
VGNC:13022
745441
Macaque
deltex E3 ubiquitin ligase 3
715175
Mouse
MGI:2135752
80904
Rat
RGD:1566181
500847
Dog
deltex E3 ubiquitin ligase 3
VGNC:40117
100687947
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deltex E3 ubiquitin ligase 3
Macaque
deltex E3 ubiquitin ligase 3
Mouse
Rat
Dog
deltex E3 ubiquitin ligase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N9I9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (32)
1 – 10 of 32
CHFR
Tbio
Family:  Enzyme
Novelty:  0.00904507
p_int:  0.999999631
p_ni:  1.27e-7
p_wrong:  2.42e-7
Score:  0.529
Data Source:  BioPlex,STRINGDB
CIAO3
Tbio
Novelty:  0.00627147
p_int:  0.999786258
p_ni:  0.000195235
p_wrong:  0.000018507
Score:  0.516
Data Source:  BioPlex,STRINGDB
NMD3
Tbio
Novelty:  0.03505289
p_int:  0.998897526
p_ni:  0.001102472
p_wrong:  2e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
p_int:  0.998517814
p_ni:  0.001482185
Score:  0.226
Data Source:  BioPlex,STRINGDB
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
p_int:  0.959475756
p_ni:  0.013469625
p_wrong:  0.027054619
Score:  0.185
Data Source:  BioPlex,STRINGDB
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.949905781
p_ni:  0.040469316
p_wrong:  0.009624902
Data Source:  BioPlex
RNF114
Tbio
Family:  Enzyme
Novelty:  0.06758257
p_int:  0.942620117
p_ni:  0.057379874
p_wrong:  9e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
GDA
Tbio
Family:  Enzyme
Novelty:  0.01846276
p_int:  0.918692367
p_ni:  0.081307633
Score:  0.209
Data Source:  BioPlex,STRINGDB
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.909840516
p_ni:  0.013584303
p_wrong:  0.076575181
Score:  0.193
Data Source:  BioPlex,STRINGDB
FARSB
Tchem
Family:  Enzyme
Novelty:  0.09683467
p_int:  0.842456568
p_ni:  0.157543432
Score:  0.226
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.88

PubMed score by year
PubTator Score  5.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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