Tbio NAT8L N-acetylaspartate synthetase

Protein Summary

Description

Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q8N9F0
• NAA synthetase

Gene Name

• NAT8L

Ensembl ID

• ENST00000423729
• ENSP00000413064
• ENSG00000185818

Symbol

• CML3
• CML3
• NACED
• NAT8-LIKE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.74
microRNA	0.61
cell type or tissue	0.52
cellular component	0.52
PubMedID	0.47

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / N-acetylaspartate Synthetase

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / N-acetylaspartate Synthetase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.45   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.45   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0