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Tbio
NAT8L
N-acetylaspartate synthetase

Protein Summary
Description
Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423729
  • ENSP00000413064
  • ENSG00000185818

Symbol
  • CML3
  • CML3
  • NACED
  • NAT8-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
microRNA
0.61
cell type or tissue
0.52
cellular component
0.52
PubMedID
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.29   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.29   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2447776
269642
Rat
RGD:1305719
289727
Dog
N-acetyltransferase 8 like
VGNC:43628
612955
Opossum
N-acetyltransferase 8 like
100015872
Anole lizard
N-acetyltransferase 8 like
100564143
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
N-acetyltransferase 8 like
Opossum
N-acetyltransferase 8 like
Anole lizard
N-acetyltransferase 8 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N9F0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Aspartate and asparagine metabolism (R-HSA-8963693)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aspartate and asparagine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Aspartate and asparagine metabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (50)
1 – 10 of 50
TSPAN5
Tbio
Novelty: 0.08879443
p_int: 0.999996838
p_ni: 0.000003155
p_wrong: 7e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
KIAA0232
Tdark
Novelty: 2.37569744
p_int: 0.914364068
p_ni: 0.061958119
p_wrong: 0.023677812
Score: 0.295
Data Source: BioPlex,STRINGDB
RIMKLA
Tdark
Family: Enzyme
Novelty: 0.30213465
Score: 0.972
Data Source: STRINGDB
RIMKLB
Tbio
Family: Enzyme
Novelty: 0.17814588
Score: 0.972
Data Source: STRINGDB
ASPA
Tbio
Family: Enzyme
Novelty: 0.02701619
Score: 0.935
Data Source: STRINGDB
FOLH1
Tchem
Family: Enzyme
Novelty: 0.0002861
Score: 0.922
Data Source: STRINGDB
GOT2
Tbio
Family: Enzyme
Novelty: 0.00054023
Score: 0.919
Data Source: STRINGDB
GOT1
Tbio
Family: Enzyme
Novelty: 0.00448817
Score: 0.918
Data Source: STRINGDB
ASS1
Tbio
Family: Enzyme
Novelty: 0.00358761
Score: 0.91
Data Source: STRINGDB
ASNS
Tchem
Family: Enzyme
Novelty: 0.00337445
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  65.29

PubMed score by year
PubTator Score  18.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer