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Tdark
RASGEF1A
Ras-GEF domain-containing family member 1A

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374459
  • ENSP00000363583
  • ENSG00000198915
  • ENST00000395809
  • ENSP00000379154
  • ENST00000395810
  • ENSP00000379155

Symbol
  • CG4853
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.59
microRNA
0.57
phenotype
0.5
cell line
0.48
cell type or tissue
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.56   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.56   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.913
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.91
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.9
Data Source:  STRINGDB
LRGUK
Tdark
Family:  Enzyme
Novelty:  0.42433819
Score:  0.717
Data Source:  STRINGDB
SBNO1
Tdark
Novelty:  0.30701767
Score:  0.646
Data Source:  STRINGDB
RIOK1
Tchem
Family:  Kinase
Novelty:  0.02476698
Score:  0.646
Data Source:  STRINGDB
RIOX1
Tbio
Family:  Epigenetic
Novelty:  0.06360414
Score:  0.645
Data Source:  STRINGDB
TGFBRAP1
Tbio
Novelty:  0.05996919
Score:  0.64
Data Source:  STRINGDB
ZNHIT6
Tbio
Novelty:  1.1021845
Score:  0.561
Data Source:  STRINGDB
FOXB1
Tbio
Family:  TF
Novelty:  0.04489092
Score:  0.548
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAPK family signaling cascades
Reactome
MAPK1/MAPK3 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAPK family signaling cascades
MAPK1/MAPK3 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (62)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
20.3
60.5
blood urea nitrogen measurement
2
2
2
48.3
BMI-adjusted hip circumference
1
1
1
26.6
central corneal thickness
1
1
0
1.5
21.5
cigarettes per day measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
20.3
60.5
blood urea nitrogen measurement
2
48.3
BMI-adjusted hip circumference
1
26.6
central corneal thickness
0
1.5
21.5
cigarettes per day measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RasGEF domain family member 1A
VGNC:5713
100615356
Macaque
RasGEF domain family member 1A
100429968
Mouse
MGI:1917977
70727
Rat
RGD:1305836
312664
Dog
RasGEF domain family member 1A
VGNC:45367
477759
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RasGEF domain family member 1A
Macaque
RasGEF domain family member 1A
Mouse
Rat
Dog
RasGEF domain family member 1A
Publication Statistics
PubMed Score 4.56
PubMed score by year
PubTator Score 2.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title