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Tbio
JMY
Junction-mediating and -regulatory protein

Protein Summary
Description
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396137
  • ENSP00000379441
  • ENSG00000152409

Symbol
  • WHAMM2
  • WHDC1L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
microRNA
0.79
biological process
0.73
transcription factor binding site profile
0.73
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.19   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.19   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
87.7
1
1
1
79.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
87.7
1
79.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
junction mediating and regulatory protein, p53 cofactor
VGNC:4057
461784
Mouse
MGI:1913096
57748
Dog
junction mediating and regulatory protein, p53 cofactor
VGNC:42191
610323
Horse
junction mediating and regulatory protein, p53 cofactor
VGNC:19225
100073264
Cow
junction mediating and regulatory protein, p53 cofactor
VGNC:30378
528498
Species
Name
OMA
EggNOG
Inparanoid
Chimp
junction mediating and regulatory protein, p53 cofactor
Mouse
Dog
junction mediating and regulatory protein, p53 cofactor
Horse
junction mediating and regulatory protein, p53 cofactor
Cow
junction mediating and regulatory protein, p53 cofactor
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Methylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Methylation
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (45)
1 – 10 of 45
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.999999532
p_ni: 4.68e-7
Score: 0.305
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.999999411
p_ni: 5.89e-7
Score: 0.542
Data Source: BioPlex,STRINGDB
CDKN3
Tbio
Family: Enzyme
Novelty: 0.00093913
p_int: 0.999805282
p_ni: 0.000067849
p_wrong: 0.00012687
Data Source: BioPlex
PPP1R1A
Tbio
Family: Enzyme
Novelty: 0.01565981
p_int: 0.995506133
p_ni: 0.004296832
p_wrong: 0.000197036
Score: 0.349
Data Source: BioPlex,STRINGDB
SPIN3
Tdark
Novelty: 0.16670763
p_int: 0.818782691
p_ni: 0.000125987
p_wrong: 0.181091322
Data Source: BioPlex
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.976
Data Source: Reactome,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.96
Data Source: Reactome,STRINGDB
MDM2
Tchem
Family: Enzyme
Novelty: 0.00028385
Score: 0.96
Data Source: STRINGDB
TTC5
Tbio
Novelty: 0.12127698
Score: 0.945
Data Source: Reactome,STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.19

PubMed score by year
PubTator Score  11.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer