You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CNEP1R1
Nuclear envelope phosphatase-regulatory subunit 1

Protein Summary
Description
Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. This gene encodes a transmembrane protein that belongs to the Tmemb_18A family. A similar protein in yeast is a component of an endoplasmic reticulum-associated protein phosphatase complex and is thought to play a role in the synthesis of triacylglycerol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000427478
  • ENSP00000394224
  • ENSG00000205423
  • ENST00000458059
  • ENSP00000405635
  • ENST00000565457
  • ENSP00000456686
  • ENST00000566482
  • ENSP00000456294
  • ENST00000568890
  • ENSP00000456913

Symbol
  • C16orf69
  • TMEM188
  • NEP1R1
  • TMP125
  • NEP1-R1
  • TMEM188
  • C16orf69
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
transcription factor binding site profile
0.75
cell type or tissue
0.69
tissue sample
0.68
microRNA
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
CTDNEP1
Tbio
Family:  Enzyme
Novelty:  0.09348082
Score:  0.991
Data Source:  Reactome,STRINGDB
LPIN1
Tbio
Family:  Enzyme
Novelty:  0.00532624
Score:  0.955
Data Source:  STRINGDB
LPIN3
Tbio
Family:  Enzyme
Novelty:  0.01641336
Score:  0.949
Data Source:  STRINGDB
LPIN2
Tbio
Family:  Enzyme
Novelty:  0.01901948
Score:  0.942
Data Source:  STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.907
Data Source:  STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
Score:  0.907
Data Source:  STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
Score:  0.905
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.902
Data Source:  STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
Score:  0.902
Data Source:  STRINGDB
PPP3CB
Tbio
Family:  Enzyme
Novelty:  0.02156713
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Depolymerisation of the Nuclear Lamina
Reactome
M Phase
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Depolymerisation of the Nuclear Lamina
M Phase
Mitotic Prophase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
91.2
1
1
0
1.2
72.9
1
1
0
1.2
72.9
mean reticulocyte volume
1
1
1
68.8
appendicular lean mass
1
2
2
54.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
91.2
0
1.2
72.9
0
1.2
72.9
mean reticulocyte volume
1
68.8
appendicular lean mass
2
54.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CTD nuclear envelope phosphatase 1 regulatory subunit 1
VGNC:5740
746035
Macaque
CTD nuclear envelope phosphatase 1 regulatory subunit 1
694061
Mouse
MGI:1921981
382030
Rat
RGD:1308816
291914
Dog
CTD nuclear envelope phosphatase 1 regulatory subunit 1
VGNC:39393
609448
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CTD nuclear envelope phosphatase 1 regulatory subunit 1
Macaque
CTD nuclear envelope phosphatase 1 regulatory subunit 1
Mouse
Rat
Dog
CTD nuclear envelope phosphatase 1 regulatory subunit 1
Publication Statistics
PubMed Score 1.69
PubMed score by year
PubTator Score 0.28
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title