CNEP1R1
Nuclear envelope phosphatase-regulatory subunit 1
Protein Summary
Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. This gene encodes a transmembrane protein that belongs to the Tmemb_18A family. A similar protein in yeast is a component of an endoplasmic reticulum-associated protein phosphatase complex and is thought to play a role in the synthesis of triacylglycerol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
- ENST00000427478
- ENSP00000394224
- ENSG00000205423
- ENST00000458059
- ENSP00000405635
- ENST00000565457
- ENSP00000456686
- ENST00000566482
- ENSP00000456294
- ENST00000568890
- ENSP00000456913
- C16orf69
- TMEM188
- NEP1R1
- TMP125
- NEP1-R1
- TMEM188
- C16orf69
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.79 | ||
transcription factor binding site profile | 0.75 | ||
cell type or tissue | 0.69 | ||
tissue sample | 0.68 | ||
microRNA | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.69 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 12 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.69 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 12 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (64)
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Depolymerisation of the Nuclear Lamina | ||||
Reactome | M Phase | ||||
Reactome | Mitotic Prophase | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Depolymerisation of the Nuclear Lamina | ||||
M Phase | ||||
Mitotic Prophase | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 3 | 3 | 3 | 91.2 | |||||
1 | 1 | 0 | 1.2 | 72.9 | |||||
1 | 1 | 0 | 1.2 | 72.9 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 68.8 | |||||
appendicular lean mass | 1 | 2 | 2 | 54.3 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 3 | 91.2 | |||||
0 | 1.2 | 72.9 | |||||
0 | 1.2 | 72.9 | |||||
mean reticulocyte volume | 1 | 68.8 | |||||
appendicular lean mass | 2 | 54.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | VGNC:5740 | 746035 | |||||
Macaque | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | 694061 | ||||||
Mouse | MGI:1921981 | 382030 | ||||||
Rat | RGD:1308816 | 291914 | ||||||
Dog | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | VGNC:39393 | 609448 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | |||||
Macaque | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | |||||
Publication Statistics
PubMed Score 1.69
PubMed score by year
PubTator Score 0.28
PubTator score by year
Related Publications
Text Mined References (5)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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