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Tbio
ATP6V0D2
V-type proton ATPase subunit d 2

Protein Summary
Description
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285393
  • ENSP00000285393
  • ENSG00000147614

Symbol
  • VMA6
  • ATP6D2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.74
gene perturbation
0.59
cell type or tissue
0.54
biological process
0.51
cell line
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.06   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.06   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
3
3
94.9
neutrophil count
2
2
2
68.5
glomerular filtration rate
1
1
1
59.8
myeloid white cell count
1
1
1
45.7
low density lipoprotein cholesterol measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
3
94.9
neutrophil count
2
68.5
glomerular filtration rate
1
59.8
myeloid white cell count
1
45.7
low density lipoprotein cholesterol measurement
1
33.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit d2
VGNC:7586
472809
Macaque
ATPase H+ transporting V0 subunit d2
693838
Mouse
MGI:1924415
242341
Rat
RGD:1306900
297932
Dog
ATPase H+ transporting V0 subunit d2
VGNC:38274
477929
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit d2
Macaque
ATPase H+ transporting V0 subunit d2
Mouse
Rat
Dog
ATPase H+ transporting V0 subunit d2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N8Y2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (106)
1 – 10 of 106
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.999999968
p_ni:  3.2e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.999999738
p_ni:  2.62e-7
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
VMA21
Tdark
Family:  Enzyme
Novelty:  0.46129032
p_int:  0.999932317
p_ni:  0.000065671
p_wrong:  0.000002012
Score:  0.883
Data Source:  BioPlex,STRINGDB
TMEM199
Tbio
Novelty:  0.05799147
p_int:  0.999928234
p_ni:  0.000071766
Score:  0.994
Data Source:  BioPlex,STRINGDB
TCIRG1
Tbio
Family:  Enzyme
Novelty:  0.00814253
p_int:  0.999920001
p_ni:  0.000079999
Score:  0.997
Data Source:  BioPlex,STRINGDB
CCDC115
Tbio
Novelty:  0.23966137
p_int:  0.999890442
p_ni:  0.000105609
p_wrong:  0.00000395
Score:  0.986
Data Source:  BioPlex,STRINGDB
ATP6V0A1
Tbio
Family:  Enzyme
Novelty:  0.02009317
p_int:  0.999507931
p_ni:  0.000492069
Score:  0.997
Data Source:  BioPlex,STRINGDB
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
p_int:  0.999339925
p_ni:  0.000660059
p_wrong:  1.7e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
FKBP15
Tbio
Novelty:  0.0570695
p_int:  0.995910797
p_ni:  0.00408902
p_wrong:  1.83e-7
Score:  0.234
Data Source:  BioPlex,STRINGDB
SLC6A1
Tclin
Family:  Transporter
Novelty:  0.00165116
p_int:  0.97474032
p_ni:  0.020320011
p_wrong:  0.004939669
Data Source:  BioPlex
Publication Statistics
PubMed Score  24.06

PubMed score by year
PubTator Score  6.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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