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Tbio
ENAH
Protein enabled homolog

Protein Summary
Description
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366843
  • ENSP00000355808
  • ENSG00000154380
  • ENST00000366844
  • ENSP00000355809

Symbol
  • MENA
  • ENA
  • MENA
  • NDPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
ligand (protein) perturbation
0.96
virus perturbation
0.95
kinase perturbation
0.93
disease perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.71   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.71   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Generation of second messenger molecules
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Developmental Biology
Generation of second messenger molecules
Immune System
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
ZYX
Tbio
Novelty: 0.00647259
p_int: 0.999973444
p_ni: 0.000026556
Score: 0.839
Data Source: BioPlex,STRINGDB
EVL
Tbio
Novelty: 0.00507124
p_int: 0.999964564
p_ni: 0.000035436
Score: 0.999
Data Source: BioPlex,STRINGDB
VASP
Tbio
Novelty: 0.00096602
p_int: 0.999853621
p_ni: 0.000146379
Score: 0.999
Data Source: BioPlex,STRINGDB
NECTIN4
Tclin
Novelty: 0.00776653
p_int: 0.996997003
p_ni: 0.003002997
Score: 0.656
Data Source: BioPlex,STRINGDB
FBLIM1
Tbio
Novelty: 0.04280121
p_int: 0.982972567
p_ni: 0.017027433
Score: 0.309
Data Source: BioPlex,STRINGDB
PARL
Tbio
Family: Enzyme
Novelty: 0.02655644
p_int: 0.960538817
p_ni: 0.039461183
Score: 0.209
Data Source: BioPlex,STRINGDB
PRMT6
Tchem
Family: Epigenetic
Novelty: 0.02160251
p_int: 0.92540074
p_ni: 0.07459926
Score: 0.183
Data Source: BioPlex,STRINGDB
PFN2
Tbio
Novelty: 0.01070069
p_int: 0.91917266
p_ni: 0.08082734
Score: 0.986
Data Source: BioPlex,STRINGDB
TMOD3
Tbio
Novelty: 0.06428995
p_int: 0.856946556
p_ni: 0.143053443
Score: 0.266
Data Source: BioPlex,STRINGDB
BCHE
Tclin
Family: Enzyme
Novelty: 0.00041933
p_int: 0.836756244
p_ni: 0.163243756
Score: 0.166
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  23.71

PubMed score by year
PubTator Score  352.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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