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Tbio
ENAH
Protein enabled homolog

Protein Summary
Description
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366843
  • ENSP00000355808
  • ENSG00000154380
  • ENST00000366844
  • ENSP00000355809

Symbol
  • MENA
  • ENA
  • MENA
  • NDPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
ligand (protein) perturbation
0.96
virus perturbation
0.95
kinase perturbation
0.93
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.52   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.52   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
75.5
neuroticism measurement
1
1
0
5.5
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
75.5
neuroticism measurement
0
5.5
46.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ENAH, actin regulator
VGNC:14825
737268
Mouse
MGI:108360
13800
Rat
RGD:1307666
360891
Dog
ENAH, actin regulator
VGNC:40357
490390
Horse
ENAH, actin regulator
VGNC:17574
100057358
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ENAH, actin regulator
Mouse
Rat
Dog
ENAH, actin regulator
Horse
ENAH, actin regulator
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N8S7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Generation of second messenger molecules
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Developmental Biology
Generation of second messenger molecules
Immune System
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
ZYX
Tbio
Novelty: 0.00375452
p_int: 0.999973444
p_ni: 0.000026556
Score: 0.839
Data Source: BioPlex,STRINGDB
EVL
Tbio
Novelty: 0.03533257
p_int: 0.999964564
p_ni: 0.000035436
Score: 0.999
Data Source: BioPlex,STRINGDB
VASP
Tbio
Novelty: 0.00041984
p_int: 0.999853621
p_ni: 0.000146379
Score: 0.999
Data Source: BioPlex,STRINGDB
NECTIN4
Tclin
Novelty: 0.00694563
p_int: 0.996997003
p_ni: 0.003002997
Score: 0.656
Data Source: BioPlex,STRINGDB
FBLIM1
Tbio
Novelty: 0.0332985
p_int: 0.982972567
p_ni: 0.017027433
Score: 0.309
Data Source: BioPlex,STRINGDB
PARL
Tbio
Family: Enzyme
Novelty: 0.01317944
p_int: 0.960538817
p_ni: 0.039461183
Score: 0.209
Data Source: BioPlex,STRINGDB
PRMT6
Tchem
Family: Epigenetic
Novelty: 0.01734208
p_int: 0.92540074
p_ni: 0.07459926
Score: 0.183
Data Source: BioPlex,STRINGDB
PFN2
Tbio
Novelty: 0.00605366
p_int: 0.91917266
p_ni: 0.08082734
Score: 0.986
Data Source: BioPlex,STRINGDB
TMOD3
Tbio
Novelty: 0.04744699
p_int: 0.856946556
p_ni: 0.143053443
Score: 0.266
Data Source: BioPlex,STRINGDB
BCHE
Tclin
Family: Enzyme
Novelty: 0.00031267
p_int: 0.836756244
p_ni: 0.163243756
Score: 0.166
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  35.52

PubMed score by year
PubTator Score  352.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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