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Tbio
SLC25A29
Mitochondrial basic amino acids transporter

Protein Summary
Description
Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine (PubMed:24652292). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 (PubMed:19287344). Does not transport carnitine nor acylcarnitines (PubMed:24652292). Functions by both counter-exchange and uniport mechanisms (PubMed:24652292). This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions. This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359232
  • ENSP00000352167
  • ENSG00000197119
  • ENST00000392908
  • ENSP00000376640
  • ENST00000554912
  • ENSP00000450913
  • ENST00000555927
  • ENSP00000452078
  • ENST00000556505
  • ENSP00000452446

Symbol
  • C14orf69
  • ORNT3
  • CACL
  • ORNT3
  • C14orf69
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
histone modification site profile
0.83
cellular component
0.65
tissue sample
0.64
virus perturbation
0.59


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.92   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.92   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
1
22.2
high density lipoprotein cholesterol measurement
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
22.2
high density lipoprotein cholesterol measurement
1
6.9
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 29
VGNC:8208
453160
Macaque
solute carrier family 25 member 29
717444
Mouse
MGI:2444911
214663
Rat
RGD:1308104
314441
Dog
solute carrier family 25 member 29
VGNC:51687
490856
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 29
Macaque
solute carrier family 25 member 29
Mouse
Rat
Dog
solute carrier family 25 member 29
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N8R3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (39)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (29)
1 – 10 of 29
MGARP
Tbio
Novelty: 0.02883753
p_int: 0.751704182
p_ni: 0.248295818
Data Source: BioPlex
SLC25A20
Tbio
Family: Transporter
Novelty: 0.00503518
Score: 0.821
Data Source: STRINGDB
PAM16
Tbio
Family: Enzyme
Novelty: 0.04932685
Score: 0.625
Data Source: STRINGDB
TFB2M
Tbio
Family: Enzyme
Novelty: 0.02345237
Score: 0.613
Data Source: STRINGDB
SLC13A4
Tbio
Family: Transporter
Novelty: 0.01859297
Score: 0.58
Data Source: STRINGDB
MRPS21
Tdark
Novelty: 0.34886873
Score: 0.562
Data Source: STRINGDB
TTMP
Tdark
Novelty: 0.22491726
Score: 0.559
Data Source: STRINGDB
CLVS2
Tbio
Novelty: 0.95264322
Score: 0.555
Data Source: STRINGDB
FSTL5
Tbio
Novelty: 0.09979909
Score: 0.547
Data Source: STRINGDB
SCUBE3
Tbio
Novelty: 0.08124826
Score: 0.541
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.92

PubMed score by year
PubTator Score  20.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer