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Tbio
NIPA2
Magnesium transporter NIPA2

Protein Summary
Description
Acts as a selective Mg(2+) transporter. This gene encodes a possible magnesium transporter. This gene is located adjacent to the imprinted domain in the Prader-Willi syndrome deletion region of chromosome 15. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 7 and 21.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337451
  • ENSP00000337618
  • ENSG00000140157
  • ENST00000359727
  • ENSP00000352762
  • ENST00000398013
  • ENSP00000381095
  • ENST00000398014
  • ENSP00000381096
  • ENST00000539711
  • ENSP00000437746

Symbol
  • SLC57A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor perturbation
0.84
disease perturbation
0.74
histone modification site profile
0.69
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.28   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.28   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (57)
1 – 10 of 57
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.999874409
p_ni:  0.000036721
p_wrong:  0.000088869
Score:  0.181
Data Source:  BioPlex,STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.879227087
p_ni:  0.00002932
p_wrong:  0.120743593
Score:  0.179
Data Source:  BioPlex,STRINGDB
TUBGCP5
Tbio
Novelty:  0.04863776
Score:  0.996
Data Source:  STRINGDB
CYFIP1
Tbio
Novelty:  0.01758346
Score:  0.99
Data Source:  STRINGDB
NIPA1
Tbio
Novelty:  0.02398766
Score:  0.941
Data Source:  STRINGDB
CFHR1
Tbio
Novelty:  0.00676665
Score:  0.937
Data Source:  STRINGDB
CFHR3
Tbio
Novelty:  0.01779009
Score:  0.937
Data Source:  STRINGDB
MNS1
Tbio
Novelty:  0.0349986
Score:  0.816
Data Source:  STRINGDB
IGFBP2
Tchem
Novelty:  0.00083618
Score:  0.804
Data Source:  STRINGDB
UNC50
Tbio
Novelty:  0.03652325
Score:  0.751
Data Source:  STRINGDB
Pathways (3)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
55.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
non imprinted in Prader-Willi/Angelman syndrome 2
710147
Mouse
MGI:1913918
93790
Rat
RGD:1306051
308667
Dog
NIPA magnesium transporter 2
VGNC:53151
479002
Horse
NIPA magnesium transporter 2
VGNC:53149
100051099
Species
Name
OMA
EggNOG
Inparanoid
Macaque
non imprinted in Prader-Willi/Angelman syndrome 2
Mouse
Rat
Dog
NIPA magnesium transporter 2
Horse
NIPA magnesium transporter 2
Publication Statistics
PubMed Score 16.28
PubMed score by year
PubTator Score 10.29
PubTator score by year