You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ENDOV
Endonuclease V

Protein Summary
Description
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323854
  • ENSP00000317810
  • ENSG00000173818
  • ENST00000517795
  • ENSP00000461577
  • ENST00000518137
  • ENSP00000429190
  • ENST00000518901
  • ENSP00000460685
  • ENST00000518907
  • ENSP00000458361
  • ENST00000520284
  • ENSP00000458391
  • ENST00000520367
  • ENSP00000431036
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
molecular function
0.84
microRNA
0.83
tissue sample
0.67
transcription factor binding site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.66   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.66   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (63)
1 – 10 of 63
SEPHS2
Tdark
Family: Enzyme
Novelty: 0.0323148
p_int: 0.999997502
p_ni: 0.000002406
p_wrong: 9.2e-8
Score: 0.332
Data Source: BioPlex,STRINGDB
APAF1
Tbio
Family: Enzyme
Novelty: 0.00164778
p_int: 0.998815889
p_ni: 0.001073262
p_wrong: 0.000110849
Score: 0.52
Data Source: BioPlex,STRINGDB
RNF31
Tbio
Family: Enzyme
Novelty: 0.01498949
p_int: 0.984516056
p_ni: 0.015477783
p_wrong: 0.000006161
Score: 0.165
Data Source: BioPlex,STRINGDB
VWA8
Tdark
Novelty: 0.39325843
p_int: 0.878972969
p_ni: 0.121027031
Score: 0.189
Data Source: BioPlex,STRINGDB
TSC22D3
Tbio
Family: TF
Novelty: 0.00711248
p_int: 0.841294268
p_ni: 0.158633842
p_wrong: 0.00007189
Score: 0.211
Data Source: BioPlex,STRINGDB
ANKRD40
Tdark
p_int: 0.790048022
p_ni: 0.209951978
Score: 0.183
Data Source: BioPlex,STRINGDB
PDCL
Tbio
Novelty: 0.0035385
p_int: 0.762635984
p_ni: 0.237364016
Score: 0.173
Data Source: BioPlex,STRINGDB
LIG4
Tbio
Family: Enzyme
Novelty: 0.00177803
Score: 0.764
Data Source: STRINGDB
UNG
Tbio
Family: Enzyme
Novelty: 0.0013114
Score: 0.733
Data Source: STRINGDB
ITPA
Tbio
Family: Enzyme
Novelty: 0.00285702
Score: 0.729
Data Source: STRINGDB
Publication Statistics
PubMed Score  187.66

PubMed score by year
PubTator Score  39.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer