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Tbio
ENDOV
Endonuclease V

Protein Summary
Description
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323854
  • ENSP00000317810
  • ENSG00000173818
  • ENST00000517795
  • ENSP00000461577
  • ENST00000518137
  • ENSP00000429190
  • ENST00000518901
  • ENSP00000460685
  • ENST00000518907
  • ENSP00000458361
  • ENST00000520284
  • ENSP00000458391
  • ENST00000520367
  • ENSP00000431036
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
molecular function
0.84
microRNA
0.83
tissue sample
0.67
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.75   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.75   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
SEPHS2
Tdark
Family:  Enzyme
Novelty:  0.01657572
p_int:  0.999997502
p_ni:  0.000002406
p_wrong:  9.2e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
p_int:  0.998815889
p_ni:  0.001073262
p_wrong:  0.000110849
Score:  0.52
Data Source:  BioPlex,STRINGDB
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
p_int:  0.984516056
p_ni:  0.015477783
p_wrong:  0.000006161
Score:  0.165
Data Source:  BioPlex,STRINGDB
VWA8
Tdark
Novelty:  0.17546432
p_int:  0.878972969
p_ni:  0.121027031
Score:  0.189
Data Source:  BioPlex,STRINGDB
TSC22D3
Tbio
Family:  TF
Novelty:  0.00660285
p_int:  0.841294268
p_ni:  0.158633842
p_wrong:  0.00007189
Score:  0.211
Data Source:  BioPlex,STRINGDB
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.790048022
p_ni:  0.209951978
Score:  0.183
Data Source:  BioPlex,STRINGDB
PDCL
Tbio
Novelty:  0.00317454
p_int:  0.762635984
p_ni:  0.237364016
Score:  0.173
Data Source:  BioPlex,STRINGDB
LIG4
Tbio
Family:  Enzyme
Novelty:  0.00412993
Score:  0.764
Data Source:  STRINGDB
UNG
Tbio
Family:  Enzyme
Novelty:  0.00268354
Score:  0.733
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.729
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Moyamoya disease
2
3
0
2
98.9
pulse pressure measurement
2
1
2
68.8
thalamus volume
1
1
0
6.4
68.7
systolic blood pressure
2
1
2
65.6
angina pectoris
3
1
3
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Moyamoya disease
0
2
98.9
pulse pressure measurement
2
68.8
thalamus volume
0
6.4
68.7
systolic blood pressure
2
65.6
angina pectoris
3
40.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endonuclease V
VGNC:12116
743058
Macaque
endonuclease V
718099
Mouse
MGI:2444688
338371
Dog
endonuclease V
VGNC:40361
608430
Horse
endonuclease V
VGNC:17577
100056365
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endonuclease V
Macaque
endonuclease V
Mouse
Dog
endonuclease V
Horse
endonuclease V
Publication Statistics
PubMed Score 238.75
PubMed score by year
PubTator Score 39.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title