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Tbio
PTGR2
Prostaglandin reductase 2

Protein Summary
Description
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267568
  • ENSP00000267568
  • ENSG00000140043
  • ENST00000555228
  • ENSP00000450975
  • ENST00000555661
  • ENSP00000452280

Symbol
  • ZADH1
  • PGR2
  • ZADH1
  • HEL-S-298
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.86
virus perturbation
0.72
transcription factor perturbation
0.68
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.56   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.56   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (30)
1 – 10 of 30
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
p_int:  0.996929162
p_ni:  2.78e-7
p_wrong:  0.00307056
Score:  0.712
Data Source:  BioPlex,STRINGDB
MECR
Tbio
Family:  Enzyme
Novelty:  0.01395965
Score:  0.736
Data Source:  STRINGDB
LRRC74A
Tdark
Novelty:  6.05462822
Score:  0.717
Data Source:  STRINGDB
AVP
Tbio
Novelty:  0.00016475
Score:  0.716
Data Source:  STRINGDB
FAM161B
Tdark
Novelty:  0.75966762
Score:  0.699
Data Source:  STRINGDB
QRICH1
Tdark
Novelty:  0.27714699
Score:  0.582
Data Source:  STRINGDB
HARBI1
Tdark
Family:  Enzyme
Novelty:  0.22704408
Score:  0.576
Data Source:  STRINGDB
CRYZL1
Tbio
Family:  Enzyme
Novelty:  0.04435286
Score:  0.559
Data Source:  STRINGDB
ZNF451
Tbio
Family:  TF
Novelty:  0.13852406
Score:  0.555
Data Source:  STRINGDB
FCF1
Tdark
Novelty:  0.04202976
Score:  0.549
Data Source:  STRINGDB
Pathways (5)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
3
94
apolipoprotein A 1 measurement
2
2
2
86.6
high density lipoprotein cholesterol measurement
5
2
5
86.6
mean corpuscular hemoglobin concentration
1
1
1
85.9
reticulocyte count
2
1
2
85.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
94
apolipoprotein A 1 measurement
2
86.6
high density lipoprotein cholesterol measurement
5
86.6
mean corpuscular hemoglobin concentration
1
85.9
reticulocyte count
2
85.7
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin reductase 2
740765
Macaque
prostaglandin reductase 2
697996
Mouse
MGI:1916372
77219
Rat
RGD:1310518
299194
Dog
prostaglandin reductase 2
480383
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin reductase 2
Macaque
prostaglandin reductase 2
Mouse
Rat
Dog
prostaglandin reductase 2
Publication Statistics
PubMed Score 12.56
PubMed score by year
PubTator Score 5.78
PubTator score by year