RNF152
E3 ubiquitin-protein ligase RNF152
Protein Summary
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).
- ENST00000312828
- ENSP00000316628
- ENSG00000176641
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.6 | ||
histone modification site profile | 0.56 | ||
virus perturbation | 0.55 | ||
cell line | 0.54 | ||
disease | 0.53 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.18 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 2 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.18 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 2 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (6)
Reactome (4)
KEGG (1)
UniProt (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | E3 ubiquitin ligases ubiquitinate target proteins | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Protein ubiquitination | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
E3 ubiquitin ligases ubiquitinate target proteins | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Protein ubiquitination | ||||
Gene Ontology Terms (14)
Functions (4)
Components (3)
Processes (7)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (42)
1 – 10 of 42
RRAGA
Novelty: 0.02022668
Score: 0.989
Data Source: Reactome,STRINGDB
UBE2N
Novelty: 0.00620946
Score: 0.933
Data Source: Reactome,STRINGDB
UBB
Novelty: 0.00661254
Score: 0.909
Data Source: STRINGDB
UBC
Novelty: 0.00204643
Score: 0.909
Data Source: STRINGDB
RPS27A
Novelty: 0.00658124
Score: 0.909
Data Source: STRINGDB
RRAGB
Novelty: 0.02279777
Score: 0.907
Data Source: STRINGDB
UBA52
Novelty: 0.01637744
Score: 0.9
Data Source: STRINGDB
AVL9
Novelty: 0.14044287
Score: 0.724
Data Source: STRINGDB
KBTBD2
Novelty: 0.50755656
Score: 0.676
Data Source: STRINGDB
TNRC18
Novelty: 0.32654022
Score: 0.665
Data Source: STRINGDB
Publication Statistics
PubMed Score 8.18
PubMed score by year
PubTator Score 2.25
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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