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Tbio
RNF152
E3 ubiquitin-protein ligase RNF152

Protein Summary
Description
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312828
  • ENSP00000316628
  • ENSG00000176641
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.6
histone modification site profile
0.56
virus perturbation
0.55
cell line
0.54
disease
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.18   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 2   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.18   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Protein-Protein Interactions (42)
1 – 10 of 42
RRAGA
Tbio
Novelty: 0.02022668
Score: 0.989
Data Source: Reactome,STRINGDB
UBE2N
Tbio
Novelty: 0.00620946
Score: 0.933
Data Source: Reactome,STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.909
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.909
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.909
Data Source: STRINGDB
RRAGB
Tbio
Novelty: 0.02279777
Score: 0.907
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.9
Data Source: STRINGDB
AVL9
Tbio
Novelty: 0.14044287
Score: 0.724
Data Source: STRINGDB
KBTBD2
Tdark
Novelty: 0.50755656
Score: 0.676
Data Source: STRINGDB
TNRC18
Tdark
Novelty: 0.32654022
Score: 0.665
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.18

PubMed score by year
PubTator Score  2.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer