Tbio RNF152 E3 ubiquitin-protein ligase RNF152

Protein Summary

Description

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).

Uniprot Accession IDs

• Q8N8N0
• B3KV99
• Q52LA4

Gene Name

• RNF152

Ensembl ID

• ENST00000312828
• ENSP00000316628
• ENSG00000176641

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.6
histone modification site profile	0.56
virus perturbation	0.55
cell line	0.54
disease	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.93   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 2   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.93   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0