Tbio RNF152 E3 ubiquitin-protein ligase RNF152

Protein Summary

Description

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).

Uniprot Accession IDs

• Q8N8N0
• B3KV99
• Q52LA4

Gene Name

• RNF152

Ensembl ID

• ENST00000312828
• ENSP00000316628
• ENSG00000176641

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.6
histone modification site profile	0.56
virus perturbation	0.55
cell line	0.54
disease	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.86   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 2   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.86   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (42)

Explore Interacting Targets

1 – 10 of 42

• See Interactions on String-DB

RRAGA

Tbio

Novelty:  0.02022668

Score:  0.989

Data Source:  Reactome,STRINGDB

UBE2N

Tchem

Novelty:  0.00620946

Score:  0.933

Data Source:  Reactome,STRINGDB

UBB

Tbio

Novelty:  0.00661254

Score:  0.909

Data Source:  STRINGDB

UBC

Tbio

Novelty:  0.00204643

Score:  0.909

Data Source:  STRINGDB

RPS27A

Tbio

Novelty:  0.00658124

Score:  0.909

Data Source:  STRINGDB

RRAGB

Tbio

Novelty:  0.02279777

Score:  0.907

Data Source:  STRINGDB

UBA52

Tbio

Novelty:  0.01637744

Score:  0.9

Data Source:  STRINGDB

AVL9

Tbio

Novelty:  0.14044287

Score:  0.724

Data Source:  STRINGDB

KBTBD2

Tdark

Novelty:  0.50755656

Score:  0.676

Data Source:  STRINGDB

TNRC18

Tdark

Novelty:  0.32654022

Score:  0.665

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

KEGG (1)

UniProt (1)

E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

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5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	E3 ubiquitin ligases ubiquitinate target proteins	110 targets	R-HSA-8866654
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	Protein ubiquitination	130 targets	R-HSA-8852135

Name	Explore in Pharos	Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins	110 targets	R-HSA-8866654
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
Protein ubiquitination	130 targets	R-HSA-8852135

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (4)

Components (3)

Processes (7)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
ubiquitin-protein transferase activity	Inferred from Direct Assay (IDA)	UniProtKB
small GTPase binding	Inferred from Physical Interaction (IPI)	UniProtKB
ubiquitin protein ligase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
Apoptosis
Complete proteome
Lysosome
Membrane
Metal-binding
Reference proteome
Transferase
Transmembrane
Transmembrane helix
Ubl conjugation

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	ring finger protein 152		699091
Mouse	ring finger protein 152	MGI:2443787	320311
Rat	ring finger protein 152	RGD:1305251	293561
Dog	ring finger protein 152	VGNC:45641	609935
Horse	ring finger protein 152	VGNC:22447	100050623

Species	Name	OMA	EggNOG	Inparanoid
Macaque	ring finger protein 152
Mouse	ring finger protein 152
Rat	ring finger protein 152
Dog	ring finger protein 152
Horse	ring finger protein 152

Publication Statistics

PubMed Score 9.86

PubMed score by year

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PubTator Score 2.25

PubTator score by year

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Related Publications

Text Mined References (7)

GeneRif Annotations (3)

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10

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PMID	Year	Title