Tbio PDCD7 Programmed cell death protein 7

Protein Summary

Description

Promotes apoptosis when overexpressed. This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q8N8D1
• Q96AK8
• Q9Y6D7

Gene Name

• PDCD7

Ensembl ID

• ENST00000204549
• ENSP00000204549
• ENSG00000090470

Symbol

• ES18
• HES18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.81
histone modification site profile	0.66
kinase perturbation	0.66
disease perturbation	0.62
tissue sample	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.57   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.57   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0