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Tdark
PDILT
Protein disulfide-isomerase-like protein of the testis

Protein Summary
Description
Probable redox-inactive chaperone involved in spermatogenesis. This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has has an N-terminal ER-signal sequence, two thioredoxin (TRX) domains with non-classical Ser-Lys-Gln-Ser and Ser-Lys-Lys-Cys motifs, respectively, two TRX-like domains, and a C-terminal ER-retention sequence. The protein lacks oxidoreductase activity in vitro and probably functions as a chaperone. This gene's expression appears to be limited to the testis. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302451
  • ENSP00000305465
  • ENSG00000169340

Symbol
  • PDIA7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.59
cell line
0.51
biological process
0.48
molecular function
0.42
tissue
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.67   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.67   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
RABL6
Tbio
Family:  Enzyme
Novelty:  0.11501478
p_int:  0.999539501
p_ni:  0.000460485
p_wrong:  1.4e-8
Data Source:  BioPlex
ITIH2
Tbio
Novelty:  0.04886358
p_int:  0.925726997
p_ni:  0.070544565
p_wrong:  0.003728439
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.885967254
p_ni:  0.114032746
Score:  0.152
Data Source:  BioPlex,STRINGDB
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.760015313
p_ni:  0.239984687
Data Source:  BioPlex
CALR3
Tbio
Novelty:  0.04510989
Score:  0.814
Data Source:  STRINGDB
CLGN
Tbio
Novelty:  0.06204915
Score:  0.76
Data Source:  STRINGDB
ERO1A
Tbio
Novelty:  0.01022914
Score:  0.667
Data Source:  STRINGDB
TXNRD1
Tclin
Family:  Enzyme
Novelty:  0.00299018
Score:  0.644
Data Source:  STRINGDB
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
Score:  0.643
Data Source:  STRINGDB
ADAM2
Tbio
Family:  Enzyme
Novelty:  0.00586482
Score:  0.593
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
17
10
15
1.7
99.7
creatinine measurement
8
7
10
1.3
99.2
3
3
2
1.2
96.2
urinary uromodulin measurement
1
3
3
95.9
creatine measurement
4
3
0
1.2
93.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
15
1.7
99.7
creatinine measurement
10
1.3
99.2
2
1.2
96.2
urinary uromodulin measurement
3
95.9
creatine measurement
0
1.2
93.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein disulfide isomerase like, testis expressed
VGNC:9212
467917
Macaque
protein disulfide isomerase like, testis expressed
696000
Mouse
MGI:1919080
71830
Rat
RGD:1307822
293544
Dog
protein disulfide isomerase like, testis expressed
VGNC:44380
489987
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein disulfide isomerase like, testis expressed
Macaque
protein disulfide isomerase like, testis expressed
Mouse
Rat
Dog
protein disulfide isomerase like, testis expressed
Publication Statistics
PubMed Score 4.67
PubMed score by year
PubTator Score 5.03
PubTator score by year
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Related Publications
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PMID
Year
Title