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Tdark
BEND7
BEN domain-containing protein 7

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
91.1
2
2
2
67.8
smoking initiation
1
1
1
66.3
diastolic blood pressure
1
1
1
48.9
neutrophil count
1
1
1
40
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
91.1
2
67.8
smoking initiation
1
66.3
diastolic blood pressure
1
48.9
neutrophil count
1
40
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (24)
1 – 10 of 24
MBD3L1
Tbio
Novelty: 0.11297566
p_int: 0.999998814
p_ni: 0.000001186
Score: 0.677
Data Source: BioPlex,STRINGDB
LRP4
Tbio
Novelty: 0.01336125
p_int: 0.99971974
p_ni: 0.00028026
Score: 0.295
Data Source: BioPlex,STRINGDB
ZNF219
Tbio
Family: TF
Novelty: 0.17515242
p_int: 0.997674653
p_ni: 0.001466495
p_wrong: 0.000858852
Score: 0.564
Data Source: BioPlex,STRINGDB
C1QBP
Tbio
Novelty: 0.00532825
p_int: 0.994355488
p_ni: 0.005644512
Score: 0.186
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.975395749
p_ni: 0.024603978
p_wrong: 2.73e-7
Data Source: BioPlex
BEND6
Tdark
Novelty: 0.51791044
Score: 0.866
Data Source: STRINGDB
PGPEP1
Tbio
Family: Enzyme
Novelty: 0.00933029
Score: 0.794
Data Source: STRINGDB
PPM1B
Tchem
Family: Enzyme
Novelty: 0.02370446
Score: 0.695
Data Source: STRINGDB
TRIM27
Tbio
Novelty: 0.02102013
Score: 0.689
Data Source: STRINGDB
NACC1
Tbio
Novelty: 0.03367769
Score: 0.585
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.61

PubMed score by year
PubTator Score  0.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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