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Tdark
BEND7
BEN domain-containing protein 7

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GENEVA
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
70.4
neutrophil count
1
1
1
70.2
leukocyte count
1
1
1
66
diastolic blood pressure
1
1
1
59
hemoglobin measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
70.4
neutrophil count
1
70.2
leukocyte count
1
66
diastolic blood pressure
1
59
hemoglobin measurement
1
54.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BEN domain containing 7
VGNC:3814
450314
Mouse
MGI:2443100
209645
Rat
RGD:1305898
361275
Dog
BEN domain containing 7
VGNC:38433
102156489
Horse
BEN domain containing 7
VGNC:15814
100069127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BEN domain containing 7
Mouse
Rat
Dog
BEN domain containing 7
Horse
BEN domain containing 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N7W2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (24)
1 – 10 of 24
MBD3L1
Tbio
Novelty:  0.11297566
p_int:  0.999998814
p_ni:  0.000001186
Score:  0.677
Data Source:  BioPlex,STRINGDB
LRP4
Tbio
Novelty:  0.01336125
p_int:  0.99971974
p_ni:  0.00028026
Score:  0.295
Data Source:  BioPlex,STRINGDB
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.997674653
p_ni:  0.001466495
p_wrong:  0.000858852
Score:  0.564
Data Source:  BioPlex,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.994355488
p_ni:  0.005644512
Score:  0.186
Data Source:  BioPlex,STRINGDB
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.975395749
p_ni:  0.024603978
p_wrong:  2.73e-7
Data Source:  BioPlex
BEND6
Tdark
Novelty:  0.51791044
Score:  0.866
Data Source:  STRINGDB
PGPEP1
Tbio
Family:  Enzyme
Novelty:  0.00933029
Score:  0.794
Data Source:  STRINGDB
PPM1B
Tchem
Family:  Enzyme
Novelty:  0.02370446
Score:  0.695
Data Source:  STRINGDB
TRIM27
Tbio
Novelty:  0.02102013
Score:  0.689
Data Source:  STRINGDB
NACC1
Tbio
Novelty:  0.03367769
Score:  0.585
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.61

PubMed score by year
PubTator Score  0.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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